CYP4F3 - cytochrome P450 family 4 subfamily F member 3 Gene

Homo sapiens

Also known as CPF3; CYP4F; LTB4H; CYPIVF3

Gene ID: 4051 | Gene type: protein coding

About CYP4F3

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:15,640,897-15,662,825 (from NCBI)

This gene has 9 transcripts (splice variants), 364 orthologues and 12 paralogues. Biased expression in liver (RPKM 51.6), bone marrow (RPKM 29.9) and 6 other tissues.

Summary

This gene, CYP4F3, encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. This protein localizes to the endoplasmic reticulum. The Enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of Cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2019]

CYP4F3 Products(4)

mRNA	Protein	Name
NM_000896.3	NP_000887.2	cytochrome P450 4F3 isoform a
NM_001199208.2	NP_001186137.1	cytochrome P450 4F3 isoform b
NM_001199209.2	NP_001186138.1	cytochrome P450 4F3 isoform b
NM_001369696.1	NP_001356625.1	cytochrome P450 4F3 isoform b

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables 20-aldehyde-leukotriene B4 20-monooxygenase activity	IDA IDA: Inferred from direct assay	9675028	GOA
enables 20-hydroxy-leukotriene B4 omega oxidase activity	IDA IDA: Inferred from direct assay	9675028	GOA
enables leukotriene-B4 20-monooxygenase activity	IDA IDA: Inferred from direct assay	9675028	GOA
enables long-chain fatty acid omega-1 hydroxylase activity	IDA IDA: Inferred from direct assay	18577768	GOA
enables long-chain fatty acid omega-hydroxylase activity	IDA IDA: Inferred from direct assay	11461919	GOA
enables very long-chain fatty acid omega-hydroxylase activity	IDA IDA: Inferred from direct assay	18577768	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in fatty acid omega-oxidation	IDA IDA: Inferred from direct assay	18577768	GOA
involved in leukotriene B4 catabolic process	IDA IDA: Inferred from direct assay	9675028	GOA
involved in lipoxin A4 metabolic process	IDA IDA: Inferred from direct assay	15364545	GOA
involved in lipoxin B4 metabolic process	IDA IDA: Inferred from direct assay	15364545	GOA
involved in omega-hydroxylase P450 pathway	IDA IDA: Inferred from direct assay	15364545	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYP4F3 Protein Structure

p450

0
100
200
300
400
520 a.a.

Protein Preferred Names

Protein Names

cytochrome P450 4F3

20-HETE synthase

Related Diseases

Diseases

Alias

Inflammatory Bowel Disease 6

IBD6

Trichuriasis

Whipworm Infection	Whipworm Disease
Trichocephaliasis	Infection By Trichuris Trichura
Trichuriasis Infection	Trichuris Trichiura Infection
Infection By Trichuris Trichiura	Trichocephalosis
Infection By Trichocephalus Trichiura	Infection By Trichuris
Infection By Trichuris Trichiuria	Trichuriosis
Whipworm	Infection Due To Trichuris Trichiura
Trichocephalus Infestation	Trichuris Infestation
Whipworm Infestation

Neuropathy, Hereditary Sensory And Autonomic, Type Ic

HSAN1C	Hsan Ic
Hsn1c	Hsn Ic
Hereditary Sensory And Autonomic Neuropathy Type 1c	Neuropathy, Hereditary Sensory And Autonomic, Type 1c
Neuropathy, Hereditary Sensory, Type Ic	Hereditary Sensory And Autonomic Neuropathy Type Ic
Neuropathy, Hereditary Sensory And Autonomic, 1c	Hereditary Sensory Neuropathy Type Ic
Neuropathy, Hereditary Sensory/Autonomic, Type Ic	Neuropathy, Sensory And Autonomic, Hereditary, Type Ic

Bietti Crystalline Corneoretinal Dystrophy

BCD	Bietti Crystalline Dystrophy
Bietti Tapetoretinal Degeneration With Marginal Corneal Dystrophy	Bietti Crystalline Retinopathy
Bietti'S Crystalline Dystrophy	Crystalline Retinopathy
Dystrophy, Corneoretinal, Crystalline, Bietti

Gliosarcoma

Glioblastoma With Sarcomatous Component

Sarcomatous Glioblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03482	CYP4F3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-113777	22-HDHA		/	Unkown
HY-121888	20-HEPE	Agonist	/	Unkown
HY-E70498	Human CYP4F3,Low-Reductase		/	Unkown
HY-E70499	Human CYP4F3,High-Reductase		/	Unkown
HY-E70500	Human CYP4F3,Low-Reductase+b5		/	Unkown
HY-E70501	Human CYP4F3,High-Reductase+b5		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CYP4F3	RGD	RGD:1305261

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