MAN2A1 - mannosidase alpha class 2A member 1 Gene

Homo sapiens

Also known as MANA2; MANII; GOLIM7; AMan II

Gene ID: 4124 | Gene type: protein coding

About MAN2A1

Cytogenetic location: 5q21.3 Genomic coordinates (GRCh38): 5:109,689,927-109,869,625 (from NCBI)

This gene has 6 transcripts (splice variants), 169 orthologues and 4 paralogues. Ubiquitous expression in duodenum (RPKM 14.9), colon (RPKM 14.2) and 25 other tissues.

Summary

This gene encodes a glycosyl hydrolase that localizes to the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus. [provided by RefSeq, Dec 2013]

MAN2A1 Products(1)

mRNA	Protein	Name
NM_002372.4	NP_002363.2	alpha-mannosidase 2

Gene Ontology

Cellular Component

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi medial cisterna	IDA IDA: Inferred from direct assay	21525244	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAN2A1 Protein Structure

Glyco_hydro_38

Alpha-mann_mid

Glyco_hydro_38C

0
200
400
600
800
1000
1144 a.a.

Protein Preferred Names

Protein Names

alpha-mannosidase 2

Golgi alpha-mannosidase II

Related Diseases

Diseases

Alias

Congenital Dyserythropoietic Anemia

Congenital Dyshaematopoietic Anaemia	Dyserythropoietic Anemia, Congenital
Cda	Anemia, Dyserythropoietic, Congenital
Anemia Dyserythropoietic Congenital	Cda - [Congenital Dyserythropoietic Anaemia]
Dyserythropoietic Dyshaematopoietic Congenital Anaemia	Dyshaematopoietic Anaemia
Dyserythropoietic Anaemia

Systemic Autoimmune Disease

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Mannosidosis, Beta A, Lysosomal

Beta-Mannosidosis	Lysosomal Beta-Mannosidase Deficiency
Beta-Mannosidase Deficiency	Beta-D-Mannosidosis
Mannosidosis, Beta	MANSB
Lysosomal Beta A Mannosidosis

Alzheimer Disease 2

AD2	Alzheimer Disease Associated With Apoe4
Alzheimer'S Disease 2	Alzheimer Disease-2
Alzheimer Disease 2, Late-Onset	Alzheimer Disease 2, Late Onset
Late-Onset Alzheimer Disease	Alzheimer Disease, Type 2
Alzheimer Disease, Late Onset

Immunodeficiency 47

Congenital Disorder Of Glycosylation Type Ii	CDG2E
Congenital Disorder Of Glycosylation Type Iie	IMD47
Cdg2s	Cdg Iis
Cdgiis	Immunodeficiency And Hepatopathy With Or Without Neurologic Features
Congenital Disorder Of Glycosylation, Type Ii	CDG1I
Congenital Disorder Of Glycosylation, Type Iie	Cdg Iie
Congenital Disorder Of Glycosylation Type 2e	Congenital Disorder Of Glycosylation, Type Iis
Cdg Ii	Cdgii
Cdgiie	Carbohydrate Deficient Glycoprotein Syndrome Type Iie
Cdg Syndrome Type Iie	Congenital Disorder Of Glycosylation Ii
Congenital Disorder Of Glycosylation 1i	Cdg-Iie
Alg2-Cdg	Cdg-Ii
Glycosylation, Congenital Disorder Of, Type Ii	Cdgiide
Congenital Disorder Of Glycosylation Type Iis	Cog7-Cdg
Cdg Syndrome Type Ii	Carbohydrate Deficient Glycoprotein Syndrome Type Ii
Congenital Disorder Of Glycosylation Type 1i	Mannosyltransferase 2 Deficiency
Congenital Disorder Of Glycosylation 2e	Congenital Disorder Of Glycosylation 2s
Congenital Disorders Of Glycosylation Type Ii	Glycosylation, Congenital Disorder Of, Type Iie
Immunodeficiency, Type 47	Congenital Disorder Of Glycosylation Type 2a

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Congenital Disorder Of Glycosylation, Type In

Congenital Disorder Of Glycosylation	CDG1N
Congenital Disorders Of Glycosylation	Cdg In
Cdgin	Congenital Disorder Of Glycosylation 1n
Carbohydrate-Deficient Glycoprotein Syndrome	Cdg
Rft1-Cdg	Cdg-In
Congenital Disorder Of Glycosylation Type In	Carbohydrate Deficient Glycoprotein Syndrome
Cdg Syndrome	Congenital Disorder Of Glycosylation In
Carbohydrate-Deficient Glycoprotein Syndromes	Cdg Syndrome Type In
Carbohydrate Deficient Glycoprotein Syndrome Type In	Congenital Disorder Of Glycosylation Type 1n
Man5glcnac2-Pp-Dol Flippase Deficiency	Glycosylation, Congenital Disorder Of
Glycosylation, Congenital Disorder Of, Type In

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08008	MAN2A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08010	MAN2B1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08012	MAN2C1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MAN2A1	VGNC	VGNC:81449
Bos taurus	MAN2A1	VGNC	VGNC:31164
Mus musculus	MAN2A1	MGD	MGI:104669
Felis catus	MAN2A1	VGNC	VGNC:97490
Rattus norvegicus	MAN2A1	RGD	RGD:3038
Canis familiaris	MAN2A1	VGNC	VGNC:42945

Name
Email *

	Sorry, but the email address you supplied was invalid.