2. Gene
  3. ART4 - ADP-ribosyltransferase 4 (inactive) (Dombrock blood group) Gene

ART4 - ADP-ribosyltransferase 4 (inactive) (Dombrock blood group) Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DO; DOK1; ARTC4; CD297; DO/ART4

Gene ID: 420 | Gene type: protein coding

About ART4

Cytogenetic location: 12p12.3 Genomic coordinates (GRCh38): 12:14,825,569-14,843,526 (from NCBI)

This gene has 4 transcripts (splice variants), 589 orthologues, 3 paralogues and is associated with 1 phenotype. Biased expression in liver (RPKM 8.6), spleen (RPKM 7.9) and 11 other tissues.

Summary

This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known. [provided by RefSeq, Jul 2008]

ART4 Products(2)

mRNA Protein Name
NM_001354646.2 NP_001341575.1 ecto-ADP-ribosyltransferase 4 isoform 2 precursor
NM_021071.4 NP_066549.2 ecto-ADP-ribosyltransferase 4 isoform 1 precursor

ART4 Protein Structure

ART

ART: NAD:arginine ADP-ribosyltransferase (56 - 276)

  • 0
  • 100
  • 200
  • 314 a.a.
Protein Preferred Names Protein Names

ecto-ADP-ribosyltransferase 4

ADP-ribosyltransferase 4 (DO blood group)

Related Diseases

Diseases Alias
Blood Group, Dombrock System

DO

Dombrock Blood Group System
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01046 ART4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ART4 VGNC VGNC:48874
Bos taurus ART4 VGNC VGNC:49134
Rattus norvegicus ART4 RGD RGD:1306456
Macaca mulatta ART4 VGNC VGNC:108323
Felis catus ART4 VGNC VGNC:83503
Mus musculus ART4 MGD MGI:1202710
Macaca fascicularis ART4 NCBI NCBI:102134161
Others ART4 NCBI