CD99 - CD99 molecule (Xg blood group) Gene

Homo sapiens

Also known as MIC2; HBA71; MIC2X; MIC2Y; MSK5X

Gene ID: 4267 | Gene type: protein coding

About CD99

Cytogenetic location: Xp22.33 Genomic coordinates (GRCh38): X:2,691,295-2,741,309 (from NCBI)

This gene has 15 transcripts (splice variants), 154 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 38.2), gall bladder (RPKM 35.8) and 25 other tissues.

Summary

The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin Cytoskeleton and may also act as an oncosuppressor in osteosarcoma. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. There is a related pseudogene located immediately adjacent to this locus. [provided by RefSeq, Mar 2016]

CD99 Products(6)

mRNA	Protein	Name
NM_001122898.3	NP_001116370.1	CD99 antigen isoform b precursor
NM_001321367.2	NP_001308296.1	CD99 antigen isoform c precursor
NM_001321368.2	NP_001308297.1	CD99 antigen isoform d precursor
NM_001321369.2	NP_001308298.1	CD99 antigen isoform e precursor
NM_001321370.2	NP_001308299.1	CD99 antigen isoform f precursor
NM_002414.5	NP_002405.1	CD99 antigen isoform a precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20374249	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD99 Protein Structure

CD99L2

0
100
185 a.a.

Protein Preferred Names

Protein Names

CD99 antigen

E2 antigen

Recombinant CD99 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70752	CD99 Protein, Human (HEK293, Fc)	P14209-1 (D23-D122)	≥95%
HY-P77623	CD99 Protein, Human (HEK293, His)	P14209-1 (D23-D122)	≥95%

Related Diseases

Diseases

Alias

Extraosseous Ewing Sarcoma

Extraosseous Ewing'S Sarcoma	Extraosseous Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Extraskeletal Ewing Sarcom	Sarcoma Extraosseous Ewings
Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor

Lymphoblastic Lymphoma

Lymphoma, Lymphoblastic	Lymphoma Lymphoblastic
Precursor Cell Lymphoblastic Lymphoma	Precursor Cell Lymphoblastic Leukemia Lymphoma

Ewing Sarcoma

Neuroepithelioma	Ewing'S Tumor
Primitive Neuroectodermal Tumor	Ewings Sarcoma
Ewing'S Sarcoma	Peripheral Neuroepithelioma
ES	Ewings Sarcoma-Primitive Neuroectodermal Tumor
Localized Peripheral Primitive Neuroectodermal Tumor	Peripheral Primitive Neuroectodermal Tumor
Ewing Tumor	Sarcoma, Ewing'S
Ewing Family Of Tumors	Extraosseous Ewing Tumor
Askin Tumor	Ewing'S Family Localized Tumor
Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor	Localized Ewing Sarcoma
Localized Ewing'S Sarcoma	Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Localized Ewing'S Tumor	Pnet Of Thoracopulmonary Region
Tumor Of The Ewing Family	Skeletal Ewing Sarcoma
Osseous Ewing Sarcoma	Ppnet
Peripheral Pnet	Extraskeletal Ewing Sarcoma
Eoe	Extraosseous Ewing Sarcoma
Extraskeletal Ewing Tumor	Esft
Ewing Sarcoma Family Of Tumors	Pne
Pnet	Pnet Of The Chest Wall
Sarcoma, Ewing	Neuroectodermal Tumors, Primitive, Peripheral
Neuroectodermal Tumor, Primitive	Disorder Of Eye
Askin'S Tumor	Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Neuroepithelioma, Peripheral

Olfactory Neuroblastoma

Esthesioneuroblastoma	Asthesioneuroblastoma
Esthesioneuroepithelioma	Olfactory Esthesioneuroblastoma
Paranasal Sinus Olfactory Neuroblastoma	Esthesioneuroblastoma, Olfactory
Esthesioneuroblastoma Of Nasal Cavity

Intracranial Primitive Neuroectodermal Tumor

Intracranial Pnet

Intracranial Primitive Neuroectodermal Neoplasm

Testicular Fibroma

Mixed Endometrial Stromal And Smooth Muscle Tumor

Stromomyoma

Mixed Endometrial Stromal And Smooth Muscle Neoplasm

Askin'S Tumor

Askin Tumor	Askin Tumour
Askin'S Tumour

Epidural Spinal Canal Neoplasm

Extradural Tumor	Epidural Neoplasms
Epidural Neoplasm

Myocardium Cancer

Malignant Myocardial Tumor	Malignant Neoplasm Of Myocardium
Tumor Of Myocardium	Malignant Tumor Of Myocardium

Cerebellopontine Angle Primitive Neuroectodermal Tumor

Cerebellopontine Angle Pnet

Colon Carcinoma In Situ

Carcinoma In Situ Of Colon	Stage 0 Colonic Carcinoma
Stage 0 Carcinoma Of Colon	Intraepithelial Neoplasia Of Colon, High Grade
Carcinoma In Situ Of Cecum	Carcinoma In Situ Of Hepatic Flexure
Carcinoma In Situ Of Ileocecal Valve	Carcinoma In Situ Of Hepatic Flexure Of Colon

Intestine Carcinoma In Situ

Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor

Extraosseous Ewing'S Tumor	Extraosseous Ewing'S Tumour
Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumour

Ectomesenchymoma

Rhabdomyosarcoma With Ganglionic Differentiation

Malignant Ectomesenchymoma

Central Nervous System Mesenchymal Non-Meningothelial Tumor

Central Nervous System Mesenchymal Non-Meningothelial Tumour	Non-Meningothelial Mesenchymal Tumor
Non-Meningothelial Mesenchymal Tumour

Small Cell Osteogenic Sarcoma

Small Cell Osteosarcoma	Round Cell Osteosarcoma
Osteosarcoma Small Cell

Teratoma

Teratomas

Desmoplastic Small Round Cell Tumor

Dsrct	Desmoplastic Small Round-Cell Tumor
Desmoplastic Small Round-Cell Neoplasm

Pulmonary Vein Leiomyosarcoma

Leiomyosarcoma Of The Pulmonary Vein

Retroperitoneal Neuroblastoma

Malignant Olfactory Nerve Neoplasm

Malignant Olfactory Nerve Tumor	Malignant Tumor Of Olfactory Nerve
Primary Malignant Neoplasm Of Olfactory Nerve

Ewing Sarcoma Of Bone

Ewing'S Sarcoma Of Bone	Bone Ewing Sarcoma
Bone Ewing'S Sarcoma	Bone Localized Ewing Sarcoma
Bone Localized Ewing'S Sarcoma	Ewing'S Sarcoma/Bone Peripheral Primitive Neuroectodermal Tumor
Localized Skeletal Ewing'S Sarcoma	Localized Bone Ewing Sarcoma

Conventional Osteosarcoma

Intracortical Osteosarcoma	Conventional Central Osteosarcoma
Intracortical Osteogenic Sarcoma	Medullary Osteosarcoma

Ganglioneuroma

Cranial Nerve Malignant Neoplasm

Cranial Nerve Neoplasms	Malignant Neoplasm Of Cranial Nerve
Malignant Tumor Of Cranial Nerve	Malignant Tumor Of The Cranial Nerve

Fibroma

Supratentorial Primitive Neuroectodermal Tumor

Supratentorial Pnet	Supratentorial Embryonal Tumor, Not Otherwise Specified
Ewings Sarcoma-Primitive Neuroectodermal Tumor

Central Nervous System Primitive Neuroectodermal Neoplasm

Cpnet

Monophasic Synovial Sarcoma

Monophasic Sarcoma Of Synovium

Meninges Hemangiopericytoma

Hemangiopericytoma Of Meninges

Meningeal Hemangiopericytoma

Testicular Granulosa Cell Tumor

Granulosa Cell Tumor Of Testis	Granulosa Cell Tumour Of Testis
Testicular Granulosa Cell Tumour

Extraskeletal Mesenchymal Chondrosarcoma

Mesenchymal Extraosseous Chondrosarcoma

Epithelioid Cell Synovial Sarcoma

Synovial Sarcoma, Epithelioid Cell

Epithelioid Synovial Sarcoma

Synovium Cancer

Malignant Tumor Of Synovium

Synovial Neoplasm

Bone Osteosarcoma

Osteosarcoma Of Bone

Primary Osteosarcoma Of Bone

Congenital Toxoplasmosis

Toxoplasmosis, Congenital	Mother-To-Child Transmission Of Toxoplasmosis
Toxoplasma Embryofetopathy	Toxoplasma Embryopathy
Toxoplasmosis - Congen.	Toxoplasmosis Congenital

Mesenchymal Chondrosarcoma

Chondrosarcoma, Mesenchymal

Chondrosarcoma Mesenchymal

Juvenile Type Testicular Granulosa Cell Tumor

Juvenile Granulosa Cell Tumor	Juvenile Granulosa Cell Tumour
Juvenile Type Granulosa Cell Neoplasm	Juvenile Type Granulosa Cell Tumor
Juvenile Type Granulosa Cell Tumour	Juvenile Type Testicular Granulosa Cell Tumour

Skeletal Muscle Cancer

Malignant Tumor Of Skeletal Muscle

Skeletal Muscle Neoplasm

Biphasic Synovial Sarcoma

Synovial Sarcoma, Biphasic

Biphasic Sarcoma Of Synovium

Coccidiosis

Intestinal Coccidiosis

Enteric Coccidiosis

Castleman Disease

Angiofollicular Ganglionic Hyperplasia	Angiofollicular Lymph Hyperplasia
Giant Lymph Node Hyperplasia	Castleman'S Disease
Angiofollicular Lymph Node Hyperplasia	Lymphoid Hamartoma
Benign Giant Lymphoma	Angiolymphoid Hyperplasia

Malignant Teratoma

Immature Teratoma	Malignant Extragonadal Teratoma
Primary Malignant Extragonadal Teratoma	Teratoma, Malignant, Nos
Teratoma, Malignant	Immature Extragonadal Teratoma

Muscle Cancer

Myosarcoma	Malignant Neoplasm Of Muscle
Malignant Tumor Of Muscle	Malignant Tumor Of The Muscle
Muscle Neoplasms	Myomatous Neoplasm

Medulloepithelioma

Diktyoma, Malignant	Medulloepithelioma, Central Nervous System
Medulloepithelioma Of The Central Nervous System

Rhabdomyosarcoma

Kidney Fibrosarcoma

Fibrosarcoma Of The Kidney

Solitary Fibrous Tumor/Hemangiopericytoma

Sft/Hpc

Sarcoma, Synovial

Synovial Sarcoma	Synovialosarcoma
Synovial Cell Sarcoma	Sarcoma Synovial

Chondrosarcoma, Extraskeletal Myxoid

Extraskeletal Myxoid Chondrosarcoma	Emc
Myxoid Extraosseous Chondrosarcoma

Embryonal Rhabdomyosarcoma

Rhabdomyosarcoma, Embryonal	Rhabdomyosarcoma Embryonal
Botryoid Rhabdomyosarcoma	Erms
Spindle Cell Rhabdomyosarcomas

Kidney Clear Cell Sarcoma

Clear Cell Sarcoma Of Kidney	Childhood Kidney Clear Cell Sarcoma
Renal Clear Cell Sarcoma	Ccsk
Clear Cell Sarcoma Of The Kidney

Rhabdomyosarcoma 2

Alveolar Rhabdomyosarcoma	Rhabdomyosarcoma, Alveolar
Rhabdomyosarcoma Alveolar	RMS2
Rmsa	Rhabdomyosarcoma 2, Alveolar
Alveolar Childhood Rhabdomyosarcoma	Arms
Rhabdomyosarcoma, Type 2

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150047	BK60106	Inducer	/	Unkown
HY-150048	BK50164		/	Unkown
HY-RS02280	CD99 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02281	CD99L2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CD99	MGD	MGI:1913728
Rattus norvegicus	CD99	RGD	RGD:1594332
Bos taurus	CD99	VGNC	VGNC:50554
Canis familiaris	CD99	VGNC	VGNC:54127