2. Gene
  3. MICB - MHC class I polypeptide-related sequence B Gene

MICB - MHC class I polypeptide-related sequence B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PERB11.2

Gene ID: 4277 | Gene type: protein coding

About MICB

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,494,918-31,511,124 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 405 orthologues and 22 paralogues. Broad expression in lymph node (RPKM 4.7), bone marrow (RPKM 4.2) and 20 other tissues.

Summary

This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind Peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

MICB Products(3)

mRNA Protein Name
NM_001289160.2 NP_001276089.1 MHC class I polypeptide-related sequence B isoform 2
NM_001289161.2 NP_001276090.1 MHC class I polypeptide-related sequence B isoform 3 precursor
NM_005931.5 NP_005922.2 MHC class I polypeptide-related sequence B isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables natural killer cell lectin-like receptor binding IDA
IDA: Inferred from direct assay
11491531 GOA
Biological Process GO Annotation Evidence Reference Source
involved in gamma-delta T cell activation IDA
IDA: Inferred from direct assay
9497295 GOA
involved in immune response-activating cell surface receptor signaling pathway IDA
IDA: Inferred from direct assay
11491531 GOA
involved in negative regulation of defense response to virus by host IDA
IDA: Inferred from direct assay
11239445 GOA
involved in response to heat IDA
IDA: Inferred from direct assay
9497295 GOA
involved in response to oxidative stress IDA
IDA: Inferred from direct assay
11287116 GOA
involved in response to retinoic acid IDA
IDA: Inferred from direct assay
12569559 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MICB Protein Structure

MHC_I

MHC_I: Class I Histocompatibility antigen, domains alpha 1 and 2 (25 - 198)

C1-set

C1-set: Immunoglobulin C1-set domain (218 - 290)

  • 0
  • 100
  • 200
  • 300
  • 383 a.a.
Protein Preferred Names Protein Names

MHC class I polypeptide-related sequence B

MHC class I antigen-related protein B

Recombinant MICB Proteins

Cat. No. Product Name Accession Purity
HY-P73293 MICB Protein, Human (HEK293, His-Fc) Q29980-1/NP_005922.2 (A23-G298) ≥95%
HY-P73294 MICB Protein, Human (HEK293, His) NP_005922.2 (A23-G298) ≥95%
HY-P78174 MICB Protein, Human (Biotinylated, HEK293, His-Avi) Q29980-1 (A23-G298) ≥95%
HY-P78491 MICB Protein, Human (HEK293, His-Avi) Q29980-1 (A23-G298) ≥95%
HY-P701023 MICB Protein, Human (HEK293, hFc) Q29980-1 (A23-G298) ≥95%

MICB Antibodies

Cat. No. Product Name Application Reactivity
HY-P81721 MICB Antibody (YA1466) FC, ELISA Human

Related Diseases

Diseases Alias
Herpes Simplex

Herpes Simplex Infections

Herpesvirus Hominis Disease

Herpes Simplex Disease

Herpesviral Infection Due To Herpes Simplex

Infections Due To Simplex Virus

Herpes Nos
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Asymptomatic Dengue
Behcet Syndrome

Behcet Disease

Behcet'S Syndrome

Behcet'S Disease

Behçet Disease

Bd

Adamantiades-Behcet Disease

Triple Symptom Complex

Behçet'S Disease

Behet'S Syndrome

Bd Syndrome

Behçet Syndrome

Behçet'S Syndrome

Behcet Triple Symptom Complex

Malignant Aphthosis

Old Silk Route Disease

Adamantiades-Behçet Disease
Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint
Celiac Disease 1

Celiac Disease

Coeliac Disease

Celiac Sprue

Celiac Disease, Susceptibility To

Gluten-Sensitive Enteropathy

Nontropical Sprue

Sprue

CELIAC1

Celiac Disease, Susceptibility To, 1

Celiac Sprue 1

Celiac Sprue, Susceptibility To, 1

Gluten-Sensitive Enteropathy 1

Gluten-Sensitive Enteropathy, Susceptibility To, 1

Idiopathic Steatorrhea

Cœliac Disease

Gluten Intolerance

Gluten-Induced Enteropathy

Gluten Enteropathy

Celiac Disease, Susceptibility To, Type 1

Childhood Celiac Disease

Coeliac Rickets

Gee Disease

Gee-Herter Disease

Heubner-Herter Disease

Idiopathic Steatorrhoea

Thaysen'S Disease

Herter Gee Syndrome
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101780A Tinostamustine hydrochloride Inhibitor / Unkown
HY-RS08430 MICB Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990467 Anti-MICB Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MICB MGD MGI:2179989
Rattus norvegicus MICB RGD RGD:1564508