MMP17 - matrix metallopeptidase 17 Gene

Homo sapiens

Also known as MMP-17; MT4MMP; MTMMP4; MT4-MMP

Gene ID: 4326 | Gene type: protein coding

About MMP17

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:131,828,393-131,851,771 (from NCBI)

This gene has 9 transcripts (splice variants), 257 orthologues and 23 paralogues. Broad expression in brain (RPKM 3.8), skin (RPKM 1.6) and 16 other tissues.

Summary

This gene encodes a member of the peptidase M10 family and membrane-type subfamily of Matrix Metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature Protease. This protein is unique among the membrane-type Matrix Metalloproteinases in that it is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor. Elevated expression of the encoded protein has been observed in osteoarthritis and multiple human cancers. [provided by RefSeq, Jan 2016]

MMP17 Products(13)

mRNA	Protein	Name
XM_047428862.1	XP_047284818.1	matrix metalloproteinase-17 isoform X6
XR_001748705.2
XM_047428860.1	XP_047284816.1	matrix metalloproteinase-17 isoform X4
XM_047428861.1	XP_047284817.1	matrix metalloproteinase-17 isoform X5
XR_944552.3
NM_016155.7	NP_057239.4	matrix metalloproteinase-17 isoform 1 precursor
XM_047428859.1	XP_047284815.1	matrix metalloproteinase-17 isoform X3
XM_011538355.4	XP_011536657.1	matrix metalloproteinase-17 isoform X1
XM_011538357.3	XP_011536659.1	matrix metalloproteinase-17 isoform X1
NM_001411000.1	NP_001397929.1	matrix metalloproteinase-17 isoform 2
XR_944551.3
XM_017019307.2	XP_016874796.1	matrix metalloproteinase-17 isoform X2
XM_011538356.4	XP_011536658.1	matrix metalloproteinase-17 isoform X1

MMP17 Protein Structure

PG_binding_1

Peptidase_M10

Hemopexin

0
100
200
300
400
500
603 a.a.

Protein Preferred Names

Protein Names

matrix metalloproteinase-17

MT-MMP 4	matrix metallopeptidase 17 (membrane-inserted)
matrix metalloproteinase 17 (membrane-inserted)	membrane-type matrix metalloproteinase 4
membrane-type-4 matrix metalloproteinase

Related Diseases

Diseases

Alias

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Winchester Syndrome

WNCHRS	Winchester Disease
Winchester-Grossman Syndrome

Aortic Aneurysm, Familial Thoracic 1

Thoracic Aortic Aneurysm	Annuloaortic Ectasia
Familial Thoracic Aortic Aneurysm And Aortic Dissection	Familial Aortic Dissection
Familial Taad	Congenital Aneurysm Of Ascending Aorta
Familial Aortic Aneurysm	Familial Thoracic Aortic Aneurysm
Familial Thoracic Aortic Aneurysm And Dissection	Aortic Aneurysm, Thoracic
AAT1	Faa1
Aortic Dissection, Familial	Aortic Aneurysm, Familial Thoracic
Aneurysm, Thoracic Aortic	Faa
Ftaad	Taa
Taad	Cystic Medial Necrosis Of Aorta
Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection	Aortic Aneurysm Thoracic
Familial Aortic Aneurysms	Aneurysm, Aortic, Thoracic, Familial, Type 1
Aneurysm Of Thoracic Aorta	Intrathoracic Aneurysm
Thoracic Aorta Aneurysm	Thoracic Aortic Aneurysm Without Rupture
Thoracic Aneurysm	Thorax Arterial Aneurysm
Thoracic Artery Aneurysm	Thoracic Arterial Aneurysm
Thorax Aneurysm	Thorax Aortic Aneurysm
Dissection Of Thoracic Aorta

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110397	KP-457	Inhibitor	99.18%	Unkown
HY-110397G	KP-457 (GMP)	Inhibitor	/	Unkown
HY-RS08533	MMP17 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08534	Mmp17 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08535	Mmp17 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MMP17	VGNC	VGNC:59062
Mus musculus	MMP17	MGD	MGI:1346076
Bos taurus	MMP17	VGNC	VGNC:31522
Rattus norvegicus	MMP17	RGD	RGD:1311541
Macaca mulatta	MMP17	VGNC	VGNC:74895
Felis catus	MMP17	VGNC	VGNC:68285

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