ASGR2 - asialoglycoprotein receptor 2 Gene

Homo sapiens

Also known as HL-2; HBXBP; ASGPR2; ASGP-R2; CLEC4H2

Gene ID: 433 | Gene type: protein coding

About ASGR2

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,101,322-7,115,146 (from NCBI)

This gene has 7 transcripts (splice variants), 141 orthologues and 14 paralogues. Biased expression in liver (RPKM 120.6) and gall bladder (RPKM 6.7).

Summary

This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic Infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

ASGR2 Products(5)

mRNA	Protein	Name
NM_001181.4	NP_001172.1	asialoglycoprotein receptor 2 isoform a
NM_001201352.2	NP_001188281.1	asialoglycoprotein receptor 2 isoform d
NM_080912.3	NP_550434.1	asialoglycoprotein receptor 2 isoform a
NM_080913.3	NP_550435.1	asialoglycoprotein receptor 2 isoform b
NM_080914.2	NP_550436.1	asialoglycoprotein receptor 2 isoform c

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11408579	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum quality control compartment	IDA IDA: Inferred from direct assay	11408579	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	11408579	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASGR2 Protein Structure

Lectin_N

Lectin_C

0
100
200
311 a.a.

Protein Preferred Names

Protein Names

asialoglycoprotein receptor 2

C-type lectin domain family 4 member H2

Recombinant ASGR2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76736	ASGR2/ASGPR2 Protein, Human (HEK293, His)	P07307 (Q80-A311)	≥95%

Related Diseases

Diseases

Alias

Hepatitis

Chronic Hepatitis	Chronic Persistent Hepatitis
Acute Hepatitis	Hepatitis, Chronic
Acute And Subacute Liver Necrosis	Acute/Subac. Necrosis Of Liver
Animal Hepatitis	Hepatitis Chronic
Hepatitis A	Hepatitis, Animal
Hepatitis Due To Toxoplasmosis	Hepatitis In Toxoplasmosis
Toxoplasmal Hepatitis	Chronic Hepatitis, Unspecified
Chronic Active Hepatitis Nec	Other Specified Chronic Hepatitis
Chronic Persistent Hepatitis Nec	Chronic Lobular Hepatitis Nec

Hepatitis B

Chronic Hepatitis B	Hepatitis B Infection
Serum Hepatitis	HBV
Hepatitis B Chronic	Hbv, Susceptibility To
Hepatitis B, Chronic	Chronic Hepatitis B Without Delta Agent
Chronic Hbv - [Hepatitis B Virus] Infection	Hepatitis B Nos
Chronic Type B Viral Hepatitis	Hep B Nos

Autoimmune Hepatitis

Aih	Hepatitis, Autoimmune
Autoimmune Chronic Active Hepatitis	Autoimmune Hepatitis With Centrilobular Necrosis
Autoimmune Chronic Hepatitis	Hepatitis Autoimmune

Liver Cirrhosis

Cirrhosis	Cirrhosis Of Liver
CIRRH	Cryptogenic Cirrhosis
Cirrhosis, Cryptogenic	Cirrhosis Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01086	ASGR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ASGR2	VGNC	VGNC:53264
Rattus norvegicus	ASGR2	RGD	RGD:2161
Bos taurus	ASGR2	VGNC	VGNC:55035
Macaca mulatta	ASGR2	VGNC	VGNC:99121
Mus musculus	ASGR2	MGD	MGI:88082
Others	ASGR2	NCBI

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