KLK12 - kallikrein related peptidase 12 Gene

Homo sapiens

Also known as KLKL5; KLK-L5

Gene ID: 43849 | Gene type: protein coding

About KLK12

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,029,094-51,035,002 (from NCBI)

This gene has 8 transcripts (splice variants), 173 orthologues and 12 paralogues. Biased expression in esophagus (RPKM 4.6), salivary gland (RPKM 1.0) and 4 other tissues.

Summary

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel Cancer and Other disease biomarkers. This gene is one of the fifteen Kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

KLK12 Products(7)

mRNA	Protein	Name
NM_001370125.1	NP_001357054.1	kallikrein-12 isoform 2 precursor
NM_001370126.1	NP_001357055.1	kallikrein-12 isoform 4
NM_001370127.1	NP_001357056.1	kallikrein-12 isoform 3
NM_001370128.1	NP_001357057.1	kallikrein-12 isoform 3
NM_019598.3	NP_062544.1	kallikrein-12 isoform 1 precursor
NM_145894.2	NP_665901.1	kallikrein-12 isoform 2 precursor
NM_145895.2	NP_665902.2	kallikrein-12 isoform 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables peptidase activity	IDA IDA: Inferred from direct assay	21628462	GOA
enables serine-type peptidase activity	IDA IDA: Inferred from direct assay	15300858	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in proteolysis	IDA IDA: Inferred from direct assay	21628462	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLK12 Protein Structure

Trypsin

0
100
200
248 a.a.

Protein Preferred Names

Protein Names

kallikrein-12

kallikrein-like protein 5

Related Diseases

Diseases

Alias

Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis	Congenital Ichthyosiform Erythroderma
Li	Congenital Nonbullous Ichthyosiform Erythroderma
Arci	Congenital Lamellar Ichthyosis
Nonbullous Congenital Ichthyosiform Erythroderma	Cie
Congenital Non-Bullous Ichthyosiform Erythroderma	Erythrodermic Ichthyosis
Nbcie	Ncie
Non-Bullous Congenital Ichthyosiform Erythroderma	Collodion Baby
Ichthyosis, Lamellar	Non Bullous Congenital Ichthyosiform Erythroderma
Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form	Ichthyosiform Erythroderma, Congenital, Nonbullous, 1
Collodion Baby Syndrome	Ichthyoses, Lamellar
Nbie	Nonbullous Ichthyosiform Erythroderma
Classic Lamellar Ichthyosis	Ichthyosiform Erythroderma Nonbullous Congenital
Ichthyosiform Erythroderma Congenital	Ichthyosis, Congenital, Autosomal Recessive
Ichthyosiform Erythroderma, Congenital	Collodion Fetus
Non-Bullous Ichthyosiform Erythroderma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07376	KLK12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KLK12	MGD	MGI:1916761
Bos taurus	KLK12	VGNC	VGNC:30674
Felis catus	KLK12	VGNC	VGNC:67963
Rattus norvegicus	KLK12	RGD	RGD:1308975
Macaca mulatta	KLK12	VGNC	VGNC:74190

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