TMEM41B - transmembrane protein 41B Gene

Homo sapiens

Gene ID: 440026 | Gene type: protein coding

About TMEM41B

This gene has 7 transcripts (splice variants), 211 orthologues and 2 paralogues. Ubiquitous expression in duodenum (RPKM 11.2), thyroid (RPKM 10.7) and 25 other tissues.

Summary

Involved in autophagosome assembly. Located in endoplasmic reticulum membrane and mitochondria-associated endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM41B Products(2)

mRNA	Protein	Name
NM_001165030.3	NP_001158502.1	transmembrane protein 41B isoform 2
NM_015012.4	NP_055827.1	transmembrane protein 41B isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phospholipid scramblase activity	IDA IDA: Inferred from direct assay	33850023	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	30093494	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in autophagosome assembly	IMP IMP: Inferred from mutant phenotype	30093494	GOA
involved in intracellular lipid transport	IDA IDA: Inferred from direct assay	34043740	GOA
involved in modulation by host of viral RNA genome replication	IDA IDA: Inferred from direct assay	34043740	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	34043740	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	30093494	GOA
located in mitochondria-associated endoplasmic reticulum membrane contact site	IDA IDA: Inferred from direct assay	30352685	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM41B Protein Structure

SNARE_assoc

0
100
200
291 a.a.

Protein Preferred Names

Protein Names

transmembrane protein 41B

protein stasimon

Related Diseases

Diseases

Alias

Yellow Fever

Urban Yellow Fever	Jungle Yellow Fever
Sylvatic Yellow Fever	Yf
Yellow Fever, Sylvan	Bronze John
Yellow Jack	Yf- [Yellow Fever]
Febris Flava

Alkhurma Hemorrhagic Fever

Alkhumra Haemorrhagic Fever

Kyasanur Forest Disease

Kfd	Monkey Fever
Kfd Virus	Kyasanur Hemorrhagic Fever
Monkey Disease	Monkey Diseases
Kfd - [ Kyasanur Forest Disease]	Monkey Sickness

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14723	TMEM41B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TMEM41B	VGNC	VGNC:47580
Felis catus	TMEM41B	VGNC	VGNC:66345
Mus musculus	TMEM41B	MGD	MGI:1289225
Bos taurus	TMEM41B	VGNC	VGNC:36086
Rattus norvegicus	TMEM41B	RGD	RGD:1310870
Macaca mulatta	TMEM41B	VGNC	VGNC:79754

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