RHEX - regulator of hemoglobinization and erythroid cell expansion Gene

Homo sapiens

Also known as C1orf186

Gene ID: 440712 | Gene type: protein coding

About RHEX

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:206,053,173-206,102,449 (from NCBI)

This gene has 5 transcripts (splice variants) and 71 orthologues. Broad expression in endometrium (RPKM 4.0), gall bladder (RPKM 2.3) and 16 other tissues.

Summary

Enables erythropoietin receptor binding activity. Involved in erythropoietin-mediated signaling pathway and positive regulation of erythrocyte differentiation. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

RHEX Products(2)

mRNA	Protein	Name
NM_001007544.4	NP_001007545.1	regulator of hemoglobinization and erythroid cell expansion protein
NM_001369490.1	NP_001356419.1	regulator of hemoglobinization and erythroid cell expansion protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables erythropoietin receptor binding	IDA IDA: Inferred from direct assay	25092874	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25092874	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to erythropoietin	IMP IMP: Inferred from mutant phenotype	25092874	GOA
involved in erythropoietin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	25092874	GOA
involved in positive regulation of erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	25092874	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	25092874	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

regulator of hemoglobinization and erythroid cell expansion protein

regulator of human erythroid cell expansion protein

RHEX Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RHEX	Q6ZWK4	SH3GLB1	Homo sapiens	Q9Y371	Validated Y2H	32296183
Intra	RHEX	Q6ZWK4	RBFA	Homo sapiens	Q8N0V3	Validated Y2H	32296183
Intra	RHEX	Q6ZWK4	SH3GL1	Homo sapiens	Q99961	Validated Y2H	32296183
Intra	RHEX	Q6ZWK4	PBX3	Homo sapiens	Q96AL5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Gallbladder Benign Neoplasm

Gallbladder Adenoma

Biliary Tract Benign Neoplasm

Extrahepatic Bile Duct Neoplasm	Neoplasm Of Extrahepatic Bile Ducts
Tumor Of The Extrahepatic Bile Duct

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11943	RHEX Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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