LMOD2 - leiomodin 2 Gene

Homo sapiens

Also known as CLMOD; CMD2G; C-LMOD

Gene ID: 442721 | Gene type: protein coding

About LMOD2

Cytogenetic location: 7q31.32 Genomic coordinates (GRCh38): 7:123,655,866-123,664,290 (from NCBI)

This gene has 2 transcripts (splice variants), 240 orthologues and 6 paralogues. Restricted expression toward heart (RPKM 307.4).

Summary

Enables actin monomer binding activity and tropomyosin binding activity. Involved in actin nucleation; positive regulation of actin filament polymerization; and sarcomere organization. Located in actin filament and sarcomere. Colocalizes with M band. [provided by Alliance of Genome Resources, Apr 2022]

LMOD2 Products(1)

mRNA	Protein	Name
NM_207163.3	NP_997046.1	leiomodin-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin binding	IDA IDA: Inferred from direct assay	18403713	GOA
enables actin monomer binding	IMP IMP: Inferred from mutant phenotype	25250574	GOA
enables tropomyosin binding	IMP IMP: Inferred from mutant phenotype	25250574	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin nucleation	IDA IDA: Inferred from direct assay	20685966	GOA
involved in actin nucleation	IMP IMP: Inferred from mutant phenotype	25250574	GOA
involved in positive regulation of actin filament polymerization	IDA IDA: Inferred from direct assay	26370058	GOA
involved in sarcomere organization	IMP IMP: Inferred from mutant phenotype	18403713	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with M band	IDA IDA: Inferred from direct assay	18403713	GOA
located in actin filament	IDA IDA: Inferred from direct assay	26370058	GOA
located in myofibril	IDA IDA: Inferred from direct assay	20685966	GOA
located in sarcomere	IDA IDA: Inferred from direct assay	18403713	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LMOD2 Protein Structure

Tropomodulin

0
100
200
300
400
500
547 a.a.

Protein Preferred Names

Protein Names

leiomodin-2

cardiac leiomodin

Related Diseases

Diseases

Alias

Cardiomyopathy, Dilated, 2g

CMD2G

Dilated Cardiomyopathy 2g

Familial Isolated Dilated Cardiomyopathy

Familial Or Idiopathic Dilated Cardiomyopathy

Nemaline Myopathy 10

NEM10

Myopathy, Nemaline, Type 10

Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 1

Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome	Berdon Syndrome
MMIHS	Megacystis Microcolon Intestinal Hypoperistalsis Syndrome
Megacystis, Microcolon, Hypoperistalsis Syndrome	Visceral Myopathy
Mmih Syndrome	Megacystis-Microcolon-Intestinal Hypoperistalsis-Hydronephrosis Syndrome
MMIHS1	Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome, Mmih
Mmhs

Autoimmune Epilepsy

Congenital Structural Myopathy

Hemoglobin H Disease

HBH	Hemoglobin H Disease, Nondeletional
Hemoglobin H Disease, Deletional	Alpha-Thalassemia Intermedia
Haemoglobin H Disease	Alpha-Thalassemia, Hemoglobin H Type
Hemoglobin H Disease, Deletional And Nondeletional	Alpha Thalassemia, Haemoglobin H Type
Alpha Thalassemia, Hemoglobin H Type	Haemoglobin H Disease, Deletional
Hbh Disease	Alpha-Thalassemia Hemoglobin H Type
Hemoglobin H Disease Deletional	Hemoglobin H Disease Non-Deletional
Alpha-Thalassemia	Alpha - /- - Or Mutational Forms Of Alpha-Thalassaemia
Alpha Thalassaemia Intermedia

Congenital Fiber-Type Disproportion

Congenital Fiber Type Disproportion	Cftdm
Congenital Myopathy With Fiber Type Disproportion	Cftd
Congenital Fiber-Type Disproportion Myopathy	Fiber-Type Disproportion Myopathy, Congenital
Myopathy, Congenital With Fiber-Type Disproportion

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy	Cardiomyopathy, Hypertrophic
Cardiomyopathy Hypertrophic Obstructive	Cardiomyopathy, Hypertrophic, Familial
Idiopathic Myocardial Hypertrophy	Idiopathic Hypertrophic Cardiomyopathy
Obstructive Idiopathic Hypertrophic Cardiomyopathy	Obstructive Cardiomyopathy
Idiopathic Hypertrophic Subaortic Stenosis	Muscular Subaortic Stenosis
Hypertrophic Obstructive Subaortic Stenosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07723	LMOD2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LMOD2	VGNC	VGNC:81634
Felis catus	LMOD2	VGNC	VGNC:80611
Canis familiaris	LMOD2	VGNC	VGNC:54785
Mus musculus	LMOD2	MGD	MGI:2135672
Bos taurus	LMOD2	VGNC	VGNC:30939
Rattus norvegicus	LMOD2	RGD	RGD:1592092

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