MT1A - metallothionein 1A Gene

Homo sapiens

Also known as MT1; MTC; MT1S; MT-1A; MT-IA

Gene ID: 4489 | Gene type: protein coding

About MT1A

Cytogenetic location: 16q13 Genomic coordinates (GRCh38): 16:56,638,666-56,640,087 (from NCBI)

This gene has 1 transcript (splice variant), 214 orthologues and 11 paralogues. Broad expression in liver (RPKM 10.5), adrenal (RPKM 7.7) and 15 other tissues.

Summary

This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. The conserved cysteine residues co-ordinate metal ions using mercaptide linkages. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. Disruption of two metallothionein genes in mouse resulted in defects in protection against heavy metals, oxidative stress, immune reactions, carcinogens, and displayed obesity. [provided by RefSeq, Sep 2017]

MT1A Products(1)

mRNA	Protein	Name
NM_005946.3	NP_005937.2	metallothionein-1A

MT1A Protein Structure

Metallothio

0
61 a.a.

Protein Preferred Names

Protein Names

metallothionein-1A

metallothionein 1A (functional)

MT1A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MT1A	P04731	TP53	Homo sapiens	P04637	Anti Bait CoIP	16442532

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Menkes Disease

Copper Transport Disease	Menkes Syndrome
MNK	Kinky Hair Disease
Steely Hair Disease	Menkes Kinky-Hair Syndrome
Mk	Steely Hair Syndrome
Menkea Syndrome	Md
Menkes Kinky Hair Syndrome	Hypocupremia, Congenital
Kinky Hair Syndrome	X-Linked Copper Deficiency
Menkes Kinky Hair Disease

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08735	MT1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MT1A	MGD	MGI:97171
Rattus norvegicus	MT1A	RGD	RGD:3117
Others	MT1A	NCBI

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