MT1G - metallothionein 1G Gene

Homo sapiens

Also known as MT1; MT1K

Gene ID: 4495 | Gene type: protein coding

About MT1G

Cytogenetic location: 16q13 Genomic coordinates (GRCh38): 16:56,666,730-56,668,065 (from NCBI)

This gene has 4 transcripts (splice variants), 218 orthologues and 11 paralogues. Biased expression in kidney (RPKM 963.2), thyroid (RPKM 736.8) and 7 other tissues.

Summary

Enables zinc ion binding activity. Involved in cellular response to metal ion; cellular response to vascular endothelial growth factor stimulus; and negative regulation of growth. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

MT1G Products(2)

mRNA	Protein	Name
NM_001301267.2	NP_001288196.1	metallothionein-1G isoform 2
NM_005950.3	NP_005941.1	metallothionein-1G isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12646258	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	8119276	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to cadmium ion	IEP IEP: Inferred from expression pattern	3403543	GOA
involved in cellular response to copper ion	IEP IEP: Inferred from expression pattern	3403543	GOA
involved in cellular response to vascular endothelial growth factor stimulus	IEP IEP: Inferred from expression pattern	15735762	GOA
involved in cellular response to zinc ion	IDA IDA: Inferred from direct assay	7559655	GOA
involved in cellular response to zinc ion	IEP IEP: Inferred from expression pattern	3403543	GOA
involved in negative regulation of growth	IDA IDA: Inferred from direct assay	18332874	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	3403543	GOA
located in nucleus	IDA IDA: Inferred from direct assay	7559655	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MT1G Protein Structure

Metallothio

0
62 a.a.

Protein Preferred Names

Protein Names

metallothionein-1G

MT-1G

MT1G Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MT1G	P13640	SPINK7	Homo sapiens	P58062	Y2H	12970870
Intra	MT1G	P13640	SPINK7	Homo sapiens	P58062	Y2H	12646258

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08739	MT1G Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MT1G	MGD	MGI:97171

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