MTIF2 - mitochondrial translational initiation factor 2 Gene

Homo sapiens

Gene ID: 4528 | Gene type: protein coding

About MTIF2

Cytogenetic location: 2p16.1 Genomic coordinates (GRCh38): 2:55,236,595-55,269,248 (from NCBI)

This gene has 12 transcripts (splice variants), 189 orthologues and 18 paralogues. Ubiquitous expression in colon (RPKM 8.3), thyroid (RPKM 7.3) and 25 other tissues.

Summary

During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. [provided by RefSeq, Mar 2016]

MTIF2 Products(7)

mRNA	Protein	Name
NM_001005369.1	NP_001005369.1	translation initiation factor IF-2, mitochondrial isoform a precursor
NM_001321001.1	NP_001307930.1	translation initiation factor IF-2, mitochondrial isoform a precursor
NM_001321002.1	NP_001307931.1	translation initiation factor IF-2, mitochondrial isoform a precursor
NM_001321003.1	NP_001307932.1	translation initiation factor IF-2, mitochondrial isoform a precursor
NM_001321004.1	NP_001307933.1	translation initiation factor IF-2, mitochondrial isoform a precursor
NM_001321005.1	NP_001307934.1	translation initiation factor IF-2, mitochondrial isoform b
NM_002453.3	NP_002444.2	translation initiation factor IF-2, mitochondrial isoform a precursor

MTIF2 Protein Structure

GTP_EFTU

GTP_EFTU_D2

IF-2

0
200
400
600
727 a.a.

Protein Preferred Names

Protein Names

translation initiation factor IF-2, mitochondrial

IF-2mt

Related Diseases

Diseases

Alias

Combined Oxidative Phosphorylation Deficiency 39

COXPD39	Combined Oxidative Phosphorylation Defect Type 39
Gfm2-Related Combined Oxidative Phosphorylation Defect

Combined Oxidative Phosphorylation Deficiency 3

Fatal Mitochondrial Disease Due To Combined Oxidative Phosphorylation Defect Type 3	COXPD3
Encephalomyopathy, Respiratory Failure, And Lactic Acidosis	Concentric Cardiomyopathy, Hypotonia, And Lactic Acidosis
Fatal Mitochondrial Disease Due To Coxpd3	Concentric Cardiomyopathy Hypotonia And Lactic Acidosis
Encephalomyopathy Respiratory Failure And Lactic Acidosis	Encephalomyopathy With Respiratory Failure And Lactic Acidosis
Combined Oxidative Phosphorylation Deficiency, Type 3

Combined Oxidative Phosphorylation Deficiency 1

Hepatoencephalopathy Due To Combined Oxidative Phosphorylation Defect Type 1	COXPD1
Early Fatal Progressive Hepatoencephalopathy	Hepatoencephalopathy Due To Coxpd1
Combined Oxidative Phosphorylation Deficiency, Type 1	Hepatoencephalopathy, Early Fatal Progressive
Hepatoencephalopathy Early Fatal Progressive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08781	MTIF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MTIF2	RGD	RGD:1303046
Mus musculus	MTIF2	MGD	MGI:1924034
Bos taurus	MTIF2	VGNC	VGNC:31733
Canis familiaris	MTIF2	VGNC	VGNC:43475
Macaca mulatta	MTIF2	VGNC	VGNC:75070
Felis catus	MTIF2	VGNC	VGNC:68341

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