MYL4 - myosin light chain 4 Gene

Homo sapiens

Also known as GT1; ALC1; AMLC; PRO1957

Gene ID: 4635 | Gene type: protein coding

About MYL4

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:47,189,433-47,227,650 (from NCBI)

This gene has 10 transcripts (splice variants), 290 orthologues, 4 paralogues and is associated with 2 phenotypes. Restricted expression toward heart (RPKM 587.0).

Summary

Myosin is a hexameric ATPase cellular motor protein. It is composed of two Myosin heavy chains, two nonphosphorylatable Myosin alkali light chains, and two phosphorylatable Myosin regulatory light chains. This gene encodes a Myosin alkali light chain that is found in embryonic muscle and adult atria. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

MYL4 Products(2)

mRNA	Protein	Name
NM_001002841.2	NP_001002841.1	myosin light chain 4
NM_002476.2	NP_002467.1	myosin light chain 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin filament binding	IMP IMP: Inferred from mutant phenotype	9738905	GOA
enables actin monomer binding	IDA IDA: Inferred from direct assay	9180271	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cardiac muscle contraction	IMP IMP: Inferred from mutant phenotype	14985854	GOA
involved in positive regulation of ATP-dependent activity	IMP IMP: Inferred from mutant phenotype	9738905	GOA
involved in regulation of the force of heart contraction	IMP IMP: Inferred from mutant phenotype	16675844	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in A band	IMP IMP: Inferred from mutant phenotype	14985854	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYL4 Protein Structure

EF-hand_6

0
100
197 a.a.

Protein Preferred Names

Protein Names

myosin light chain 4

atrial myosin light chain 1

Related Diseases

Diseases

Alias

Atrial Fibrillation, Familial, 18

ATFB18

Fibrillation, Atrial, Familial, Type 18

Familial Atrial Fibrillation

Atrial Fibrillation, Familial	Atfb
Atrial Fibrillation Autosomal Dominant	Autosomal Dominant Atrial Fibrillation
Auricular Fibrillation	Atrial Fibrillation
Atrial Fibrillation, Familial, 1

Atrial Fibrillation

A-Fib	Fibrillation, Atrial
Af - [Atrial Fibrillation]	Rapid Atrial Fibrillation
A Fib - [Atrial Fibrillation]

Aortic Valve Disease 2

Aortic Valve Stenosis	Aortic Stenosis
Rheumatic Aortic Stenosis	AOVD2
Bicuspid Aortic Valve	Rheumatic Aortic Valve Stenosis
Valvular Aortic Stenosis	Aortic Valve Disease, Type 2
Aortic Valve Stricture	Aortic Valve Obstruction
Obstructed Aorta Valve	Rheumatic Aortic Obstruction
Rheumatic Aortic Valve Obstruction	Rheumatic Aortic Stricture
Aortic Valve Regurgitation	Aortic Insufficiency With Stenosis
Rheumatic Aortic Valve Stenosis With Insufficiency	Rheumatic Aortic Stenosis With Incompetence
Rheumatic Aortic Stenosis With Regurgitation

Acute Myocardial Infarction

Cardiac Attack

Heart Attack

Pleomorphic Rhabdomyosarcoma

Adult Pleomorphic Rhabdomyosarcoma	Anaplastic Rhabdomyosarcoma
Pleomorphic Rhabdomyosarcoma, Adult Type

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Congenital Fiber-Type Disproportion

Congenital Fiber Type Disproportion	Cftdm
Congenital Myopathy With Fiber Type Disproportion	Cftd
Congenital Fiber-Type Disproportion Myopathy	Fiber-Type Disproportion Myopathy, Congenital
Myopathy, Congenital With Fiber-Type Disproportion

Cardiomyopathy, Familial Hypertrophic, 1

Asymmetric Septal Hypertrophy	Familial Hypertrophic Cardiomyopathy
Hypertrophic Cardiomyopathy 1	CMH1
Hypertrophic Cardiomyopathy 19	CMH
Ventricular Hypertrophy, Hereditary	Ash
Hypertrophic Subaortic Stenosis, Idiopathic	Cardiomyopathy, Familial Hypertrophic
Cardiomyopathy, Hypertrophic, 1, Digenic	Cardiomyopathy, Familial Hypertrophic 1
Hcm	Hereditary Ventricular Hypertrophy
Idiopathic Hypertrophic Subaortic Stenosis	Hypertrophic Cardiomyopathy
Cardiomyopathy, Hypertrophic, Familial	Cardiomyopathy, Hypertrophic, 1
Familial Asymmetric Septal Hypertrophy	Heritable Hypertrophic Cardiomyopathy
Fhc	Cardiomyopathy, Hypertrophic, Familial, Type 1

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy	Cardiomyopathy, Hypertrophic
Cardiomyopathy Hypertrophic Obstructive	Cardiomyopathy, Hypertrophic, Familial
Idiopathic Myocardial Hypertrophy	Idiopathic Hypertrophic Cardiomyopathy
Obstructive Idiopathic Hypertrophic Cardiomyopathy	Obstructive Cardiomyopathy
Idiopathic Hypertrophic Subaortic Stenosis	Muscular Subaortic Stenosis
Hypertrophic Obstructive Subaortic Stenosis

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08916	MYL4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MYL4	RGD	RGD:1591197
Canis familiaris	MYL4	VGNC	VGNC:55648
Mus musculus	MYL4	MGD	MGI:97267
Felis catus	MYL4	VGNC	VGNC:68384
Bos taurus	MYL4	VGNC	VGNC:31802
Macaca mulatta	MYL4	VGNC	VGNC:75105

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