2. Gene
  3. MYO1C - myosin IC Gene

MYO1C - myosin IC Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NMI; MMIb; myr2; MyoIC; MMI-beta

Gene ID: 4641 | Gene type: protein coding

About MYO1C

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:1,464,186-1,492,686 (from NCBI)

This gene has 20 transcripts (splice variants), 205 orthologues, 43 paralogues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 109.9), lung (RPKM 53.1) and 23 other tissues.

Summary

This gene encodes a member of the unconventional Myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene Myosin IE has been referred to as Myosin IC in the literature, but it is a distinct locus on chromosome 19. [provided by RefSeq, Jul 2008]

MYO1C Products(4)

mRNA Protein Name
NM_001080779.2 NP_001074248.1 unconventional myosin-Ic isoform a
NM_001080950.2 NP_001074419.1 unconventional myosin-Ic isoform b
NM_001363855.1 NP_001350784.1 unconventional myosin-Ic isoform d
NM_033375.5 NP_203693.3 unconventional myosin-Ic isoform c
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21402783 GOA
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
21402783 GOA
enables small GTPase binding IPI
IPI: Inferred from physical interaction
24056301 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
21402783 GOA
involved in positive regulation of transcription by RNA polymerase III IDA
IDA: Inferred from direct assay
16603771 GOA
involved in protein targeting to membrane IDA
IDA: Inferred from direct assay
21402783 GOA
involved in protein targeting to membrane IMP
IMP: Inferred from mutant phenotype
23262137 GOA
involved in regulation of bicellular tight junction assembly IMP
IMP: Inferred from mutant phenotype
21402783 GOA
involved in vascular endothelial growth factor signaling pathway IMP
IMP: Inferred from mutant phenotype
23262137 GOA
Cellular Component GO Annotation Evidence Reference Source
part of B-WICH complex IDA
IDA: Inferred from direct assay
16603771 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
21402783 GOA
located in membrane IDA
IDA: Inferred from direct assay
21402783 GOA
located in membrane raft IDA
IDA: Inferred from direct assay
23262137 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
23262137 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYO1C Protein Structure

Myosin_head

Myosin_head: Myosin head (motor domain) (56 - 718)

IQ

IQ: IQ calmodulin-binding motif (737 - 754)

IQ

IQ: IQ calmodulin-binding motif (759 - 776)

Myosin_TH1

Myosin_TH1: Unconventional myosin tail, actin- and lipid-binding (873 - 1058)

  • 0
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  • 800
  • 1000
  • 1063 a.a.
Protein Preferred Names Protein Names

unconventional myosin-Ic

myosin-I beta

Related Diseases

Diseases Alias
Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna

Autosomal Dominant Isolated Neurosensory Deafness Type Dfna

Autosomal Dominant Isolated Neurosensory Hearing Loss Type Dfna

Autosomal Dominant Isolated Sensorineural Deafness Type Dfna

Autosomal Dominant Isolated Sensorineural Hearing Loss Type Dfna

Autosomal Dominant Non-Syndromic Neurosensory Deafness Type Dfna

Autosomal Dominant Non-Syndromic Neurosensory Hearing Loss Type Dfna

Autosomal Dominant Non-Syndromic Sensorineural Hearing Loss Type Dfna
Granulomatous Amebic Encephalitis

Granulomatous Amoebic Encephalitis

Acanthamoeba Encephalitis

Acanthamoeba Granulomatous Encephalitis

Granulomatous Amebic Encephalitis Due To Acanthamoeba
Chromosome 17p13.3, Centromeric, Duplication Syndrome

Chromosome 17p13.3 Duplication Syndrome

17p13.3 Duplication Syndrome

17p13.3 Microduplication Syndrome

Trisomy 17p13.3

Chromosome 17p13.3 Centromeric Duplication Syndrome

Dup(17)(P13.3)
Primary Amebic Meningoencephalitis

Pam

Naegleria Fowleri Infection

Meningoencephalitis Caused By Naegleria Fowleri

Primary Amoebic Meningoencephalitis
Myopathy, Centronuclear, 1

Autosomal Dominant Centronuclear Myopathy

CNM1

Centronuclear Myopathy 1

Ad-Cnm

Myopathy, Centronuclear, Autosomal Dominant

Myotubular Myopathy, Autosomal Dominant

Centronuclear Myopathy, Autosomal, Modifier Of

Autosomal Dominant Myotubular Myopathy

Dnm2-Related Centronuclear Myopathy

Centronuclear Myopathy Autosomal Dominant

Myopathies, Structural, Congenital

Myopathy, Centronuclear, Type 1
Miller-Dieker Lissencephaly Syndrome

Miller-Dieker Syndrome

Mds

MDLS

Miller Dieker Syndrome

Classical Lissencephaly Syndrome

Lissencephaly Due To 17p13.3 Deletion

Monosomy 17p13.3

Telomeric Deletion 17p

Classical Lissencephaly
Amebiasis

Amoebiasis

Entamoebiasis

Chronic Intestinal Amebiasis

Amoebiasis, Unspecified

Amebic Colitis

Amoebic Enteritis

Infection Due To Entamoeba Histolytica

Amoebic Infection

Disease Due To Endamoebidae

Amoebiasis Nos
Usher Syndrome, Type I

USH1

Usher Syndrome Type 1

Us1

Usher Syndrome, Type 1b

Usher Syndrome Type 1e

Retinitis Pigmentosa And Congenital Deafness

Usher Syndrome, Type Ie

USH1E

Usher Syndrome, Type 1e

Usher Syndrome, Type 1a

Usher Syndrome, Type Ib

Usher Syndrome Type 1b

Usher Syndrome Type Ie

Usher Syndrome Type I

Usher 1

Usher Syndrome, Type 1

Ush1a

Usher Syndrome, Type I, French Variety

Usher Syndrome, Type Ia

Usher Syndrome 1b

USH1B

Usher'S Syndrome Type 1b

Usher Syndrome Type Ib

Ushib
Usher Syndrome

Deafness-Retinitis Pigmentosa Syndrome

Dystrophia Retinae Pigmentosa-Dysostosis Syndrome

Graefe-Usher Syndrome

Hallgren Syndrome

Usher'S Syndrome

Retinitis Pigmentosa-Deafness Syndrome

Retinitis Pigmentosa-Hearing Loss Syndrome

Ush

Usher Syndromes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08939 MYO1C Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MYO1C VGNC VGNC:68390
Macaca mulatta MYO1C VGNC VGNC:75112
Bos taurus MYO1C VGNC VGNC:31818
Mus musculus MYO1C MGD MGI:106612
Rattus norvegicus MYO1C RGD RGD:620443
Canis familiaris MYO1C VGNC VGNC:43562