MYO9B - myosin IXB Gene

Homo sapiens

Also known as MYR5; CELIAC4

Gene ID: 4650 | Gene type: protein coding

About MYO9B

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:17,075,777-17,215,255 (from NCBI)

This gene has 20 transcripts (splice variants), 282 orthologues, 43 paralogues and is associated with 1 phenotype. Broad expression in spleen (RPKM 30.6), bone marrow (RPKM 21.4) and 24 other tissues.

Summary

This gene encodes a member of the Myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind Calmodulin, which serves as a LIGHT chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

MYO9B Products(2)

mRNA	Protein	Name
NM_001130065.2	NP_001123537.1	unconventional myosin-IXb isoform 2
NM_004145.4	NP_004136.2	unconventional myosin-IXb isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ADP binding	IDA IDA: Inferred from direct assay	16338935	GOA
enables ATP binding	IDA IDA: Inferred from direct assay	16338935	GOA
enables GTPase activator activity	IDA IDA: Inferred from direct assay	9490638	GOA
enables Roundabout binding	IPI IPI: Inferred from physical interaction	26529257	GOA
enables actin binding	IDA IDA: Inferred from direct assay	9490638	GOA
enables calmodulin binding	IDA IDA: Inferred from direct assay	9490638	GOA
enables microfilament motor activity	IDA IDA: Inferred from direct assay	9490638	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15644318	GOA
NOT enables protein homodimerization activity	IDA IDA: Inferred from direct assay	11901422	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	26529257	GOA

Biological Process GO Annotation	Evidence	Reference	Source
NOT involved in ARF protein signal transduction	IDA IDA: Inferred from direct assay	15644318	GOA
involved in Roundabout signaling pathway	IDA IDA: Inferred from direct assay	26529257	GOA
involved in actin filament-based movement	IDA IDA: Inferred from direct assay	9490638	GOA
involved in regulation of Rho protein signal transduction	IMP IMP: Inferred from mutant phenotype	26529257	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in actin filament	IDA IDA: Inferred from direct assay	8907710	GOA
located in cell cortex	IDA IDA: Inferred from direct assay	8907710	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	8907710	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	8907710	GOA
is active in postsynaptic actin cytoskeleton	IDA IDA: Inferred from direct assay	30123108	GOA
is active in postsynaptic actin cytoskeleton	IMP IMP: Inferred from mutant phenotype	30123108	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYO9B Protein Structure

Myosin_head

RhoGAP

0
400
800
1200
1600
2000
2157 a.a.

Protein Preferred Names

Protein Names

unconventional myosin-IXb

myosin-IXb

Related Diseases

Diseases

Alias

Celiac Disease 4

Celiac Disease, Susceptibility To, 4	CELIAC4
Gluten-Sensitive Enteropathy 4	Gluten-Sensitive Enteropathy, Susceptibility To, 4
Celiac Disease, Susceptibility To, Type 4

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

Dermatitis Herpetiformis

Duhring'S Disease	Duhring-Brocq Disease
Dermatosis Herpetiformis	Brocq-Duhring Disease
Dh	Duhring Brocq Disease
Dh - [Dermatitis Herpetiformis]

Ulcerative Colitis

Colitis Gravis	Left Sided Ulcerative Colitis
Left-Sided Ulcerative Colitis	Idiopathic Proctocolitis
Inflammatory Bowel Disease, Ulcerative Colitis Type	Uc
Colitis Ulcerative	Colitis, Ulcerative
Chronic Left-Sided Ulcerative Colitis	Uc - [Ulcerative Colitis]
Chronic Ulcerative Enteritis	Mucosal Proctocolitis
Ulcerative Mucosal Proctocolitis	Left Hemicolitis

Inflammatory Bowel Disease 6

IBD6

Colitis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Jejunoileitis

Inflammatory Bowel Disease 5

IBD5

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08953	MYO9B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MYO9B	RGD	RGD:3146
Canis familiaris	MYO9B	VGNC	VGNC:43575
Felis catus	MYO9B	VGNC	VGNC:68402
Bos taurus	MYO9B	VGNC	VGNC:31832
Mus musculus	MYO9B	MGD	MGI:106624

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