NDUFB2 - NADH:ubiquinone oxidoreductase subunit B2 Gene

Homo sapiens

Also known as AGGG; CI-AGGG

Gene ID: 4708 | Gene type: protein coding

About NDUFB2

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:140,696,708-140,706,643 (from NCBI)

This gene has 15 transcripts (splice variants) and 222 orthologues. Ubiquitous expression in heart (RPKM 93.9), kidney (RPKM 78.0) and 25 other tissues.

Summary

The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays a important role in transfering electrons from NADH to the respiratory chain. The immediate electron acceptor for the Enzyme is believed to be ubiquinone. Hydropathy analysis revealed that this subunit and 4 other subunits have an overall hydrophilic pattern, even though they are found within the hydrophobic protein (HP) fraction of complex I. [provided by RefSeq, Jul 2008]

NDUFB2 Products(1)

mRNA	Protein	Name
NM_004546.3	NP_004537.1	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in mitochondrial respiratory chain complex I assembly	IMP IMP: Inferred from mutant phenotype	27626371	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	28844695	GOA
part of respiratory chain complex I	IDA IDA: Inferred from direct assay	12611891	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NDUFB2 Protein Structure

NADH_B2

0
105 a.a.

Protein Preferred Names

Protein Names

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa

Related Diseases

Diseases

Alias

Intraneural Perineurioma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09147	NDUFB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NDUFB2	VGNC	VGNC:43701
Macaca mulatta	NDUFB2	VGNC	VGNC:75156
Rattus norvegicus	NDUFB2	RGD	RGD:1308130
Mus musculus	NDUFB2	MGD	MGI:1915448
Felis catus	NDUFB2	VGNC	VGNC:80634
Bos taurus	NDUFB2	VGNC	VGNC:31962

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