NDUFB4 - NADH:ubiquinone oxidoreductase subunit B4 Gene

Homo sapiens

Also known as B15; CI-B15

Gene ID: 4710 | Gene type: protein coding

About NDUFB4

Cytogenetic location: 3q13.33 Genomic coordinates (GRCh38): 3:120,596,336-120,602,507 (from NCBI)

This gene has 6 transcripts (splice variants) and 227 orthologues. Ubiquitous expression in adrenal (RPKM 52.4), heart (RPKM 52.2) and 25 other tissues.

Summary

This gene encodes a non-catalytic subunit of the multisubunit NADH:ubiquinone oxidoreductase, the first Enzyme complex in the mitochondrial electron transport chain (complex I). Mammalian complex I is composed of 45 different subunits and transfers electrons from NADH to ubiquinone. [provided by RefSeq, Dec 2009]

NDUFB4 Products(2)

mRNA	Protein	Name
NM_001168331.2	NP_001161803.1	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 isoform 2
NM_004547.6	NP_004538.2	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 isoform 1

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in mitochondrial respiratory chain complex I assembly	IMP IMP: Inferred from mutant phenotype	27626371	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	28844695	GOA
part of respiratory chain complex I	IDA IDA: Inferred from direct assay	12611891	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NDUFB4 Protein Structure

NDUF_B4

0
100
129 a.a.

Protein Preferred Names

Protein Names

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa

Related Diseases

Diseases

Alias

Polyomavirus-Associated Nephropathy

Polyomavirus Associated Nephropathy

Pvan

Latex Allergy

Hantavirus Hemorrhagic Fever With Renal Syndrome

Hemorrhagic Fever, Russian	Hemorrhagic Nephrosonephritis
Hfrs	Puumala Virus Nephropathy
Hemorrhagic Fever With Renal Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09149	NDUFB4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NDUFB4	RGD	RGD:1307072
Felis catus	NDUFB4	VGNC	VGNC:102785
Canis familiaris	NDUFB4	VGNC	VGNC:43703
Mus musculus	NDUFB4	MGD	MGI:1915444
Macaca mulatta	NDUFB4	VGNC	VGNC:75157

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