GIMAP6 - GTPase, IMAP family member 6 Gene

Homo sapiens

Also known as IAN2; IAN6; IAN-2; IAN-6

Gene ID: 474344 | Gene type: protein coding

About GIMAP6

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:150,625,375-150,632,385 (from NCBI)

This gene has 3 transcripts (splice variants), 92 orthologues and 7 paralogues. Broad expression in spleen (RPKM 29.7), lymph node (RPKM 22.3) and 23 other tissues.

Summary

This gene encodes a member of the GTPases of immunity-associated proteins (GIMAP) family. GIMAP proteins contain GTP-binding and coiled-coil motifs, and may play roles in the regulation of cell survival. Decreased expression of this gene may play a role in non-small cell lung Cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is found in a cluster with seven additional GIMAP genes on the long arm of chromosome 7. [provided by RefSeq, Sep 2011]

GIMAP6 Products(3)

mRNA	Protein	Name
NM_001244071.2	NP_001231000.1	GTPase IMAP family member 6 isoform 3
NM_001244072.2	NP_001231001.1	GTPase IMAP family member 6 isoform 2
NM_024711.6	NP_078987.3	GTPase IMAP family member 6 isoform 1

Gene Ontology

Cellular Component

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	23454188	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GIMAP6 Protein Structure

AIG1

0
100
200
292 a.a.

Protein Preferred Names

Protein Names

GTPase IMAP family member 6

immune associated nucleotide 2

Related Diseases

Diseases

Alias

Lymphopenia

Lymphocytopenia

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05426	GIMAP6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GIMAP6	MGD	MGI:1918876
Canis familiaris	GIMAP6	VGNC	VGNC:106600
Macaca mulatta	GIMAP6	VGNC	VGNC:81315
Rattus norvegicus	GIMAP6	RGD	RGD:1305041

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