NFIA - nuclear factor I A Gene

Homo sapiens

Also known as CTF; NF1-A; NFI-A; NFI-L; BRMUTD; NF-I/A

Gene ID: 4774 | Gene type: protein coding

About NFIA

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:61,077,227-61,462,788 (from NCBI)

This gene has 31 transcripts (splice variants), 224 orthologues, 3 paralogues and is associated with 3 phenotypes. Ubiquitous expression in fat (RPKM 9.2), thyroid (RPKM 8.8) and 25 other tissues.

Summary

This gene encodes a member of the NF1 (nuclear factor 1) family of transcription factors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

NFIA Products(4)

mRNA	Protein	Name
NM_001134673.4	NP_001128145.1	nuclear factor 1 A-type isoform 1
NM_001145511.2	NP_001138983.1	nuclear factor 1 A-type isoform 3
NM_001145512.2	NP_001138984.1	nuclear factor 1 A-type isoform 4
NM_005595.5	NP_005586.1	nuclear factor 1 A-type isoform 2

NFIA Protein Structure

NfI_DNAbd_pre-N

MH1

CTF_NFI

0
100
200
300
400
509 a.a.

Protein Preferred Names

Protein Names

nuclear factor 1 A-type

CCAAT-box-binding transcription factor

Related Diseases

Diseases

Alias

Brain Malformations With Or Without Urinary Tract Defects

Chromosome 1p32-P31 Deletion Syndrome	Nfia-Related Disorder
Chromosome 1, Monosomy 1p32	BRMUTD
1p31p32 Microdeletion Syndrome	Nfia Haploinsufficiency
Del(1)(P31p32)	Monosomy 1p31p32
Nfia-Related Disorders

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

Hydrocephalus

Hydrocephalus, Nonsyndromic, Autosomal Recessive	Hydrocephalus, X-Linked
Hydrocephalus Adverse Event	Hydrocephaly Nos

Marshall-Smith Syndrome

MRSHSS	Accelerated Skeletal Maturation-Facial Dysmorphism-Failure To Thrive Syndrome
Mss

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Cellular Neurofibroma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09249	NFIA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NFIA	VGNC	VGNC:32038
Canis familiaris	NFIA	VGNC	VGNC:43775
Rattus norvegicus	NFIA	RGD	RGD:3170
Mus musculus	NFIA	MGD	MGI:108056
Felis catus	NFIA	VGNC	VGNC:68477
Macaca mulatta	NFIA	VGNC	VGNC:75334

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