NIT1 - nitrilase 1 Gene

Homo sapiens

Gene ID: 4817 | Gene type: protein coding

About NIT1

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:161,118,105-161,125,445 (from NCBI)

This gene has 16 transcripts (splice variants), 195 orthologues and 2 paralogues. Ubiquitous expression in adrenal (RPKM 11.4), kidney (RPKM 10.4) and 25 other tissues.

Summary

This gene encodes a member of the nitrilase protein family with homology to Bacterial and plant nitrilases, Enzymes that cleave nitriles and organic amides to the corresponding carboxylic acids plus ammonia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

NIT1 Products(4)

mRNA	Protein	Name
NM_001185092.2	NP_001172021.1	deaminated glutathione amidase isoform 2
NM_001185093.2	NP_001172022.1	deaminated glutathione amidase isoform 3
NM_001185094.2	NP_001172023.1	deaminated glutathione amidase isoform 4
NM_005600.3	NP_005591.1	deaminated glutathione amidase isoform 1

NIT1 Protein Structure

CN_hydrolase

0
100
200
300
327 a.a.

Protein Preferred Names

Protein Names

deaminated glutathione amidase

dGSH amidase

Related Diseases

Diseases

Alias

Pancreatic Cystadenoma

Cystadenoma Of Pancreas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10622	SHLP-3	Inhibitor	/	Unkown
HY-P10625	SHLP-6		/	Unkown
HY-RS09310	NIT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NIT1	VGNC	VGNC:75351
Rattus norvegicus	NIT1	RGD	RGD:727821
Felis catus	NIT1	VGNC	VGNC:107904
Canis familiaris	NIT1	VGNC	VGNC:53123
Bos taurus	NIT1	VGNC	VGNC:32089
Mus musculus	NIT1	MGD	MGI:1350916
Others	NIT1	NCBI

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