2. Gene
  3. NNMT - nicotinamide N-methyltransferase Gene

NNMT - nicotinamide N-methyltransferase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 4837 | Gene type: protein coding

About NNMT

Cytogenetic location: 11q23.2 Genomic coordinates (GRCh38): 11:114,257,806-114,313,536 (from NCBI)

This gene has 8 transcripts (splice variants), 142 orthologues and 2 paralogues. Biased expression in liver (RPKM 188.3), appendix (RPKM 69.3) and 10 other tissues.

Summary

N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008]

NNMT Products(4)

mRNA Protein Name
NM_001372045.1 NP_001358974.1 nicotinamide N-methyltransferase
NM_001372046.1 NP_001358975.1 nicotinamide N-methyltransferase
NM_001372047.1 NP_001358976.1 nicotinamide N-methyltransferase
NM_006169.3 NP_006160.1 nicotinamide N-methyltransferase
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables nicotinamide N-methyltransferase activity IDA
IDA: Inferred from direct assay
8182091 GOA
enables nicotinamide N-methyltransferase activity IMP
IMP: Inferred from mutant phenotype
23455543 GOA
Biological Process GO Annotation Evidence Reference Source
involved in nicotinamide metabolic process IDA
IDA: Inferred from direct assay
8182091 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NNMT Protein Structure

NNMT_PNMT_TEMT

NNMT_PNMT_TEMT: NNMT/PNMT/TEMT family (2 - 259)

  • 0
  • 100
  • 200
  • 264 a.a.
Protein Preferred Names Protein Names

nicotinamide N-methyltransferase

Recombinant NNMT Proteins

Cat. No. Product Name Accession Purity
HY-P79286 Nicotinamide N-Methyltransferase/NNMT Protein, Human (His) P40261 (M1-L264) ≥95%

Related Diseases

Diseases Alias
Pellagra

Niacin Deficiency

Niacin-Tryptophan Deficiency

Pellagroid Syndrome
Inflammatory Bowel Disease 25

Early Onset Autosomal Recessive Inflammatory Bowel Disease 25

Ibd25

Inflammatory Bowel Disease 25, Autosomal Recessive
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal Carcinoma, Chromophobe, Somatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell Carcinoma, Somatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

Carcinoma, Renal Cell

Renal Cell Carcinoma, Clear Cell, Somatic

Renal Cell Carcinoma, Clear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

Carcinoma, Renal Cell, Nonpapillary
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-112584 JBSNF-000088 99.94% Unkown
HY-131042 NNMTi Inhibitor 99.80% Unkown
HY-151500B JBSNF-000028 hydrochloride Inhibitor 95.83% Unkown
HY-151813 NNMT-IN-4 Inhibitor 99.35% Unkown
HY-151500A JBSNF-000028 TFA Inhibitor 99.47% Unkown
HY-128464 LL320 / Unkown
HY-138993 NNMT-IN-6 Inhibitor / Unkown
HY-151193 NNMT-IN-3 / Unkown
HY-151500 JBSNF-000028 free base Inhibitor / Unkown
HY-161316 NNMT-IN-5 / Unkown
HY-RS09395 NNMT Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-163174 II399 / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NNMT MGD MGI:1099443
Macaca mulatta NNMT VGNC VGNC:75362
Rattus norvegicus NNMT RGD RGD:1309606
Canis familiaris NNMT VGNC VGNC:43869
Others NNMT NCBI