Scn3a - sodium voltage-gated channel alpha subunit 3 Gene

Rattus norvegicus

Also known as SCIII; Scn2a; Nav1.3

Gene ID: 497770 | Gene type: protein coding

About Scn3a

Primary_assembly 3: 50,148,139-50,258,119 reverse strand.mRatBN7.2:CM026976.1

This gene has 4 transcripts (splice variants), 130 orthologues, 26 paralogues and is associated with 24 phenotypes. Biased expression in Brain (RPKM 164.9), Muscle (RPKM 25.) and 5 other tissues.

Summary

Enables Calmodulin binding activity; sodium ion binding activity; and voltage-gated Sodium Channel activity. Involved in several processes, including cellular response to antibiotic; neuronal action potential; and response to pyrethroid. Located in axon and neuronal cell body. Part of voltage-gated Sodium Channel complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 62 and focal epilepsy. Orthologous to human SCN3A (sodium voltage-gated channel alpha subunit 3). [provided by Alliance of Genome Resources, Apr 2022]

Scn3a Products(1)

mRNA	Protein	Name
NM_013119.2	NP_037251.2	sodium channel protein type 3 subunit alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calmodulin binding	IDA IDA: Inferred from direct assay	16912065	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15317864	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to antibiotic	IDA IDA: Inferred from direct assay	18839021	RGD
involved in nervous system development	IEP IEP: Inferred from expression pattern	19269275	RGD
involved in response to pyrethroid	IDA IDA: Inferred from direct assay	19026681	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	16966585	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	16966585	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Scn3a Protein Structure

Ion_trans

Na_trans_cytopl

Ion_trans

Na_trans_assoc

Ion_trans

Na_channel_gate

Ion_trans

0
400
800
1200
1600
1983 a.a.

Protein Preferred Names

Protein Names

sodium channel protein type 3 subunit alpha

rCG26412-like	sodium channel protein type 3 subunit alpha-like
sodium channel protein type III subunit alpha	sodium channel protein, brain III subunit alpha
sodium channel, voltage-gated, type 3, alpha subunit	sodium channel, voltage-gated, type III, alpha subunit
voltage-gated sodium channel subtype III	voltage-gated sodium channel subunit alpha Nav1.3

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12533	SCN3A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12534	Scn3a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12535	Scn3a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Scn3a	NCBI	NCBI:6328

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