Pkd2 - polycystin 2, transient receptor potential cation channel Gene

Rattus norvegicus

Also known as Trpp2; RGD1559992

Gene ID: 498328 | Gene type: protein coding

About Pkd2

Primary_assembly 14: 5,237,135-5,280,825 reverse strand.mRatBN7.2:CM026987.1

This gene has 1 transcript (splice variant), 222 orthologues, 10 paralogues and is associated with 18 phenotypes. Biased expression in Kidney (RPKM 188.3), Adrenal (RPKM 164.1) and 9 other tissues.

Summary

Enables muscle alpha-actinin binding activity. Involved in positive regulation of cytosolic calcium ion concentration. Located in endoplasmic reticulum and membrane. Biomarker of acute kidney failure. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; intracranial aneurysm; polycystic kidney disease; polycystic kidney disease 2; and retinal degeneration. Orthologous to human PKD2 (polycystin 2, transient receptor potential cation channel). [provided by Alliance of Genome Resources, Apr 2022]

Pkd2 Products(1)

mRNA	Protein	Name
NM_001191934.1	NP_001178863.1	polycystin-2

Pkd2 Protein Structure

PKD_channel

Fer4_24

0
200
400
600
800
966 a.a.

Protein Preferred Names

Protein Names

polycystin-2

polycystic kidney disease 2 (autosomal dominant)

polycystic kidney disease 2 homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15698A	CRT0066101 dihydrochloride	Inhibitor	99.92%	Unkown
HY-12239	CID755673	Inhibitor	99.13%	Unkown
HY-13941	1-Naphthyl PP1	Inhibitor	99.08%	Unkown
HY-15528	kb NB 142-70	Inhibitor	98.08%	Unkown
HY-13454	CID 2011756	Inhibitor	96.98%	Unkown
HY-15698	CRT0066101	Inhibitor	95.11%	Unkown
HY-118052	BPKDi	Inhibitor	99.60%	Unkown
HY-151374	3-IN-PP1	Inhibitor	99.58%	Unkown
HY-151372	Protein kinase D inhibitor 1	Inhibitor	/	Unkown
HY-15698B	CRT0066101 trihydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pkd2	NCBI	NCBI:5311

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