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  4. BPKDi

BPKDi is a potent bipyridyl PKD inhibitor with IC50s of 1 nM, 9 nM and 1 nM for PKD1, PKD2 and PKD3, respectively. BPKDi blocks signal-dependent phosphorylation and nuclear export of class IIa HDACs in cardiomyocytes.

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BPKDi Chemical Structure

BPKDi Chemical Structure

CAS No. : 1201673-28-0

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Based on 1 publication(s) in Google Scholar

BPKDi Related Antibodies

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PKD1 PKD2 PKD3

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Description

BPKDi is a potent bipyridyl PKD inhibitor with IC50s of 1 nM, 9 nM and 1 nM for PKD1, PKD2 and PKD3, respectively. BPKDi blocks signal-dependent phosphorylation and nuclear export of class IIa HDACs in cardiomyocytes[1].

IC50 & Target[1]

PKD1

1 nM (IC50)

PKD2

9 nM (IC50)

PKD3

1 nM (IC50)

Molecular Weight

380.49

Formula

C21H28N6O
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N)C1=CC(C2=CC(NC3CCCCC3)=NC=C2)=NC(N4CCNCC4)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (131.41 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6282 mL 13.1409 mL 26.2819 mL
5 mM 0.5256 mL 2.6282 mL 5.2564 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6282 mL 13.1410 mL 26.2819 mL 65.7048 mL
5 mM 0.5256 mL 2.6282 mL 5.2564 mL 13.1410 mL
10 mM 0.2628 mL 1.3141 mL 2.6282 mL 6.5705 mL
15 mM 0.1752 mL 0.8761 mL 1.7521 mL 4.3803 mL
20 mM 0.1314 mL 0.6570 mL 1.3141 mL 3.2852 mL
25 mM 0.1051 mL 0.5256 mL 1.0513 mL 2.6282 mL
30 mM 0.0876 mL 0.4380 mL 0.8761 mL 2.1902 mL
40 mM 0.0657 mL 0.3285 mL 0.6570 mL 1.6426 mL
50 mM 0.0526 mL 0.2628 mL 0.5256 mL 1.3141 mL
60 mM 0.0438 mL 0.2190 mL 0.4380 mL 1.0951 mL
80 mM 0.0329 mL 0.1643 mL 0.3285 mL 0.8213 mL
100 mM 0.0263 mL 0.1314 mL 0.2628 mL 0.6570 mL
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BPKDi Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BPKDi1201673-28-0PKDProtein kinase DPKD1PKD2PKD3hypertrophyclass IIa HDACsphosphorylationnuclear exportInhibitorinhibitorinhibit

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