SPRN - shadow of prion protein Gene

Homo sapiens

Also known as SHO; SHADOO; bA108K14.1

Gene ID: 503542 | Gene type: protein coding

About SPRN

Cytogenetic location: 10q26.3 Genomic coordinates (GRCh38): 10:133,420,666-133,424,625 (from NCBI)

This gene has 2 transcripts (splice variants) and 60 orthologues. Ubiquitous expression in brain (RPKM 10.6), duodenum (RPKM 4.2) and 25 other tissues.

Summary

Predicted to enable nucleic acid binding activity. Predicted to be involved in protein import into nucleus. Predicted to be located in membrane. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

SPRN Products(2)

mRNA	Protein	Name
NM_001012508.6	NP_001012526.2	shadow of prion protein precursor
NM_001391974.1	NP_001378903.1	shadow of prion protein precursor

SPRN Protein Structure

Shadoo

0
100
151 a.a.

Protein Preferred Names

Protein Names

shadow of prion protein

hypothetical protein BC004409

Related Diseases

Diseases

Alias

Scrapie

Prion Disease

Spongiform Encephalopathy	Transmissible Spongiform Encephalopathies
Prion Diseases	Prion Disease Pathway
Transmissible Spongiform Encephalopathy	Prion Induced Disorder
Prion Protein Disease	Inherited Human Transmissible Spongiform Encephalopathies
Prion Protein Diseases	Prion-Associated Disorders
Prion-Induced Disorders	Transmissible Dementias
Tses	Human Prion Disease
Tse	Encephalopathy, Transmissible Spongiform
Prion Disease, Susceptibility To	Spongiform Encephalopathies
Human Transmissible Spongiform Encephalopathies, Inherited

Creutzfeldt-Jakob Disease

Variant Creutzfeldt-Jakob Disease	CJD
Bovine Spongiform Encephalopathy	Vcjd
Inherited Creutzfeldt-Jakob Disease	Creutzfeldt-Jakob Disease, Familial
Creutzfeldt Jakob Disease	Creutzfeldt-Jacob Disease
Creutzfeldt Jacob Disease	Sporadic Creutzfeldt-Jakob Disease
Encephalopathy, Bovine Spongiform	Creutzfeldt-Jakob Disease, Variant, Resistance To
Creutzfeldt-Jakob Disease, Variant	Creutzfeldt Jacob Syndrome
Jakob-Creutzfeldt Disease	Subacute Spongiform Encephalopathy
Transmissible Virus Dementia	New Variant Of Cjd
Nv-Cjd	Variant Cjd
Variant Creutzfeldt-Jacob Disease	Sporadic Cjd
Inherited Cjd	Acquired Creutzfeldt-Jakob Disease
Variant Mcj	Encephalopathy Bovine Spongiform
Familial Creutzfeldt-Jakob Disease	Creutzfeldt-Jakob Syndrome
New Variant Creutzfeldt-Jakob Disease	Creutzfeldt-Jakob Disease, Sporadic
Acquired Cjd	Scjd - [Sporadic Creutzfeldt-Jakob Disease]
Idiopathic Creutzfeldt-Jakob Disease	Creutzfeld-Jakob Disease Nos
Vcjd - [Variant Creutzfeldt-Jakob Disease]

Chronic Wasting Disease

Wasting Disease, Chronic

Kuru

Kuru, Susceptibility To	Kuru Encephalopathy
Kuru Encephalitis	Kuru Disease

Gerstmann-Straussler Disease

Gerstmann-Straussler-Scheinker Disease	Gerstmann-Straussler-Scheinker Syndrome
Prion Dementia	Cerebral Amyloid Angiopathy, Prnp-Related
GSD	Gss
Cerebellar Ataxia, Progressive Dementia, And Amyloid Deposits In Cns	Amyloidosis, Cerebral, With Spongiform Encephalopathy
Subacute Spongiform Encephalopathy, Gerstmann-Straussler Type	Encephalopathy, Subacute Spongiform, Gerstmann-Straussler Type
Amyloidosis Cerebral With Spongiform Encephalopathy	Cerebellar Ataxia, Progressive Dementia, And Amyloid Deposits In The Central Nervous System
Encephalopathy Subacute Spongiform Gerstmann-Straussler Type	Gssd
Gerstmann Straussler Scheinker Syndrome	Cerebral Amyloidosis With Spongiform Encephalopathy
Subacute Spongiform Encephalopathy Gerstmann-Straussler Type	Gluthathione Synthetase Deficiency
Gerstmann Straussler Syndrome

Fatal Familial Insomnia

Insomnia, Fatal Familial	FFI
Familial Fatal Insomnia	Insomnia Familial Fatal
Insomnia Fatal Familial	Insomnia, Fatal, Familial
Ffi - [Fatal Familial Insomnia]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13712	SPRN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SPRN	VGNC	VGNC:35239
Mus musculus	SPRN	MGD	MGI:3582583
Canis familiaris	SPRN	VGNC	VGNC:46764
Rattus norvegicus	SPRN	RGD	RGD:1561845

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