PCSK6 - proprotein convertase subtilisin/kexin type 6 Gene

Homo sapiens

Also known as SPC4; PACE4

Gene ID: 5046 | Gene type: protein coding

About PCSK6

Cytogenetic location: 15q26.3 Genomic coordinates (GRCh38): 15:101,303,933-101,489,707 (from NCBI)

This gene has 29 transcripts (splice variants), 196 orthologues and 9 paralogues. Biased expression in spleen (RPKM 31.3), liver (RPKM 30.7) and 12 other tissues.

Summary

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression and left-right patterning. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2014]

PCSK6 Products(7)

mRNA	Protein	Name
NM_001291309.2	NP_001278238.1	proprotein convertase subtilisin/kexin type 6 isoform i preproprotein
NM_002570.5	NP_002561.1	proprotein convertase subtilisin/kexin type 6 isoform PACE4-AI preproprotein
NM_138319.4	NP_612192.1	proprotein convertase subtilisin/kexin type 6 isoform PACE4-AII preproprotein
NM_138322.4	NP_612195.1	proprotein convertase subtilisin/kexin type 6 isoform PACE4B preproprotein
NM_138323.3	NP_612196.1	proprotein convertase subtilisin/kexin type 6 isoform PACE4CS preproprotein
NM_138324.3	NP_612197.1	proprotein convertase subtilisin/kexin type 6 isoform PACE4C preproprotein
NM_138325.4	NP_612198.2	proprotein convertase subtilisin/kexin type 6 isoform f preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables endopeptidase activity	IDA IDA: Inferred from direct assay	9242664	GOA
enables heparin binding	IDA IDA: Inferred from direct assay	12535616	GOA
enables nerve growth factor binding	IDA IDA: Inferred from direct assay	8615794	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16433634	GOA
enables serine-type endopeptidase activity	IDA IDA: Inferred from direct assay	8218226	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in glycoprotein metabolic process	IDA IDA: Inferred from direct assay	8218226	GOA
involved in nerve growth factor production	IDA IDA: Inferred from direct assay	8615794	GOA
involved in peptide hormone processing	IDA IDA: Inferred from direct assay	9242664	GOA
involved in protein processing	IDA IDA: Inferred from direct assay	8218226	GOA
involved in secretion by cell	IDA IDA: Inferred from direct assay	8615794	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	12535616	GOA
located in collagen-containing extracellular matrix	IDA IDA: Inferred from direct assay	12535616	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	8906861	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PCSK6 Protein Structure

Peptidase_S8

P_proprotein

GF_recep_IV

PLAC

0
200
400
600
800
968 a.a.

Protein Preferred Names

Protein Names

proprotein convertase subtilisin/kexin type 6

paired basic amino acid cleaving enzyme 4

PCSK6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PCSK6	P29122	PCSK5	Homo sapiens	Q92824-2	Validated Y2H	32296183
Intra	PCSK6	P29122	ZNF441	Homo sapiens	Q8N8Z8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PCSK6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700617	PCSK6 Protein, Human (His)	P29122-1 (R860-G969)	≥95%
HY-P700621	PCSK6 Protein, Human (HEK293, hFc)	P29122 (R860-G969)	≥95%

Related Diseases

Diseases

Alias

Anthrax Disease

Anthrax	Ragpicker'S Disease
Black Baine	Malignant Edema
Malignant Pustule	Siberian Plague
Wool Sorter'S Disease	Gas Gangrene
Cutaneous Anthrax	Anthrax Infection
Splenic Fever

Melon Allergy

Cucumis Melo Fruit Allergy

Dyslexia

Arthrogryposis, Distal, Type 1c

DA1C	Distal Arthrogryposis Type 1c
Arthrogryposis, Distal, 1c

Hypobetalipoproteinemia, Familial, 2

Familial Hypobetalipoproteinemia 2	FHBL2
Hypolipidemia, Familial, Combined	Combined Familial Hypolipidemia
Combined Hypobetalipoproteinemia Familial	Hypobetalipoproteinemia, Familial, Type 2

Mitochondrial Complex Ii Deficiency

Isolated Mitochondrial Respiratory Chain Complex Ii Deficiency	Isolated Succinate-Coenzyme Q Reductase Deficiency
Isolated Succinate-Coq Reductase Deficiency	Isolated Succinate-Ubiquinone Reductase Deficiency
Mitochondrial Respiratory Chain Complex Ii Deficiency	Complex 2 Mitochondrial Respiratory Chain Deficiency
Succinate Coq Reductase Deficiency	Succinate Dehydrogenase Deficiency
Isolated Succinate Dehydrogenase Deficiency	Succinate-Coenzyme Q Reductase Deficiency

Malaria

Malaria, Susceptibility To	Malaria, Resistance To
Malaria, Cerebral	Cerebral Malaria
Malaria, Severe, Susceptibility To	Malaria, Severe, Resistance To
Malaria, Cerebral, Susceptibility To	Induced Malaria
Malaria, Vivax, Protection Against	Malaria, Severe
Malaria, Cerebral, Reduced Risk Of	Malaria, Protection Against
Resistance To Malaria Due To G6pd Deficiency	Malaria Due To G6pd Deficiency
Malarial Encephalitis	CM
Malaria Cerebral	Susceptibility To Malaria
Acute Pernicious Fever	Aestivo-Autumnal Fever
Aestivo Autumnal Malaria	Chagres Fever
Continued Malaria Fever	Estivo-Autumnal Fever
Estivo-Autumnal Malaria	Estivo-Autumnal Malarial Fever
Falciparum Fever	Malignant Tertian Fever
Malignant Tertian Malaria	Pernicious Intermittent Fever
Pernicious Malaria	Quotidian Malaria
Subtertian Fever	Subtertian Malaria Fever
Subtertian Malignant Tertian Malaria	Tropical Malaria
Algid Malaria	Bilious Haemoglobinuric Fever
Black Water Fever	Blackwater Fever
Malarial Blackwater Fever	Severe Malarial Falciparum
West African Fever	Malarial Haematinuria
Haemoglobinuric Fever	Haemoglobinuric Malaria
Severe Plasmodium Falciparum Malaria	Malarial Haemoglobinuria
Malarial Haematuria	Falciparum Malaria [Malignant Tertian]
Malaria Tropica	Malarial Shock
Chagres Virus Disease	Malignant Malaria
Mtm - [Malignant Tertian Malaria]	Tm -[Malignant Tertian Malaria]
Panama Fever	St - [Subtertian Malaria]
Malarial Quotidian	Benign Tertian Malaria
Tertian Ague	Vivax Fever
Plasmodium Vivax Malaria Nos	Btm - [Benign Tertian Malaria]
Bt - [Benign Tertian Malaria]	Vivax Malaria
Benign Tertian Vivax Malaria	Tertian Malaria
Quartan Malaria	Quartan Ague
Quartan Fever	Plasmodium Malariae Malaria Nos
Quartan Malarial	Malaria By Plasmodium Malariae
Malariae Malaria	Ovale Tertian Malaria
Plasmodium Ovale Fever	Malaria Fever By Plasmodium Ovale
Ovale Malaria	Malaria By Plasmodium Ovale
Malarial Ovale	Marsh Fever
Remittent Congestive Fever	Coastal Fever
Remittent Gastric Fever	Miasmatic Fever
Congestive Remittent Fever	Intermittent Fever
Jungle Fever	Paludism
Cameroon Fever	Ague
Corsican Fever	Intermittent Bilious Fever
Disease Due To Plasmodiidae	Malarial Fever
Plasmodiosis	Remittent Fever
Roman Fever	Malaria Fever Nos
Malaria Nos	Paludal Fever
Clinically Diagnosed Malaria	Clinically Diagnosed Malaria Without Parasitological Confirmation
Congestive Fever	Malarial Cachexia
Marsh Cachexia	Paludal Cachexia
Recurrent Malaria	Remittent Malaria

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10175	PCSK6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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