2. Gene
  3. Nox4 - NADPH oxidase 4 Gene

Nox4 - NADPH oxidase 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 50490 | Gene type: protein coding

About Nox4

Chromosome 7: 86,895,304-87,047,918 forward strand.GRCm39:CM001000.3

This gene has 8 transcripts (splice variants), 149 orthologues, 5 paralogues and is associated with 31 phenotypes. Biased expression in kidney adult (RPKM 51.3) and lung adult (RPKM 5.1).

Summary

Enables protein tyrosine kinase binding activity and superoxide-generating NAD(P)H oxidase activity. Involved in several processes, including positive regulation of intracellular signal transduction; positive regulation of nitrogen compound metabolic process; and superoxide anion generation. Acts upstream of or within bone resorption; cardiac muscle cell differentiation; and cellular response to glucose stimulus. Located in several cellular components, including mitochondrion; nucleus; and perinuclear region of cytoplasm. Is expressed in embryo; heart; metanephros; renal cortex; and ventricle compact myocardium. Orthologous to human NOX4 (NADPH Oxidase 4). [provided by Alliance of Genome Resources, Apr 2022]

Nox4 Products(3)

mRNA Protein Name
NM_001285833.1 NP_001272762.1 NADPH oxidase 4 isoform 2
NM_001285835.1 NP_001272764.1 NADPH oxidase 4 isoform 3
NM_015760.5 NP_056575.1 NADPH oxidase 4 isoform 1

Nox4 Protein Structure

Ferric_reduct

Ferric_reduct: pfam01794 (68 - 204)

NOX_Duox_like_FAD_NADP

NOX_Duox_like_FAD_NADP: cd06186 (310 - 576)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 578 a.a.
Protein Preferred Names Protein Names

NADPH oxidase 4

KOX-1

kidney oxidase-1

kidney superoxide-producing NADPH oxidase

renal NAD(P)H-oxidase

superoxide-generating NADPH oxidase 4

Related Agents

Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-12298 Setanaxib Inhibitor 99.45% Phase 3
HY-120801 APX-115 Inhibitor 99.58% Phase 2
HY-120801A APX-115 free base Inhibitor 98.11% Phase 2
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100111 GLX351322 Inhibitor 99.67% Unkown
HY-101499 GKT136901 Inhibitor 99.70% Unkown
HY-152026 NADPH oxidase-IN-1 Inhibitor 99.60% Unkown
HY-N3239 Mulberrofuran G Inhibitor 99.84% Unkown
HY-105946 Hidrosmin Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nox4 NCBI NCBI:50507