Pten - phosphatase and tensin homolog Gene

Rattus norvegicus

Also known as Mmac; TEP1; MMAC1

Gene ID: 50557 | Gene type: protein coding

About Pten

Primary_assembly 1: 230,630,338-230,696,838 forward strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 150 orthologues, 5 paralogues and is associated with 162 phenotypes. Biased expression in Adrenal (RPKM 635.2), Lung (RPKM 588.6) and 9 other tissues.

Summary

Enables several functions, including PDZ domain binding activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; and signaling receptor binding activity. Involved in several processes, including cellular response to hormone stimulus; dephosphorylation; and negative regulation of transport. Located in several cellular components, including dendritic spine; mitochondrion; and postsynaptic membrane. Is active in postsynaptic cytosol. Used to study portal hypertension and substance-related disorder. Biomarker of several diseases, including acute myocardial infarction; fatty liver disease; glucose metabolism disease (multiple); retinal disease (multiple); and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including PTEN hamartoma tumor syndrome (multiple); breast Cancer (multiple); gastrointestinal system Cancer (multiple); nervous system Cancer (multiple); and reproductive organ Cancer (multiple). Orthologous to human PTEN (Phosphatase and tensin homolog). [provided by Alliance of Genome Resources, Apr 2022]

Pten Products(1)

mRNA	Protein	Name
NM_031606.2	NP_113794.1	phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	20628354	RGD
enables ionotropic glutamate receptor binding	IDA IDA: Inferred from direct assay	15102920	RGD
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	IDA IDA: Inferred from direct assay	17324556	RGD
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	IMP IMP: Inferred from mutant phenotype	20628354	RGD
enables platelet-derived growth factor receptor binding	IDA IDA: Inferred from direct assay	14718524	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16474401	RGD
enables protein tyrosine kinase binding	IDA IDA: Inferred from direct assay	22609523	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to ethanol	IDA IDA: Inferred from direct assay	12700235	RGD
involved in cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	12700235	RGD
involved in cellular response to insulin-like growth factor stimulus	IDA IDA: Inferred from direct assay	12700235	RGD
involved in cellular response to leptin stimulus	IMP IMP: Inferred from mutant phenotype	24103758	RGD
involved in cellular response to nerve growth factor stimulus	IEP IEP: Inferred from expression pattern	10662831	RGD
involved in cellular response to sorbitol	IEP IEP: Inferred from expression pattern	16807353	RGD
involved in inositol phosphate catabolic process	IDA IDA: Inferred from direct assay	18056380	RGD
involved in long-term synaptic depression	IMP IMP: Inferred from mutant phenotype	20628354	RGD
involved in memory	IMP IMP: Inferred from mutant phenotype	15317872	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	30783439	RGD
involved in negative regulation of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	30783439	RGD
involved in negative regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	30783439	RGD
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	14656929	RGD
involved in negative regulation of defense response to bacterium	IMP IMP: Inferred from mutant phenotype	18056380	RGD
involved in negative regulation of dendrite extension	IMP IMP: Inferred from mutant phenotype	23028614	RGD
involved in negative regulation of neuron projection development	IDA IDA: Inferred from direct assay	28008308	RGD
involved in negative regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	18056380	RGD
involved in negative regulation of potassium ion transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	24103758	RGD
involved in negative regulation of signaling receptor activity	IMP IMP: Inferred from mutant phenotype	24044036	RGD
involved in neuron projection development	IDA IDA: Inferred from direct assay	14990793	RGD
involved in phosphatidylinositol dephosphorylation	IDA IDA: Inferred from direct assay	17324556	RGD
involved in phosphatidylinositol dephosphorylation	IMP IMP: Inferred from mutant phenotype	20628354	RGD
involved in platelet-derived growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	14718524	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16502258	RGD
involved in positive regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	22609523	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20578043	RGD
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	30783439	RGD
involved in positive regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	10662831	RGD
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	30783439	RGD
involved in protein dephosphorylation	IMP IMP: Inferred from mutant phenotype	22609523	RGD
involved in regulation of Fc receptor mediated stimulatory signaling pathway	IMP IMP: Inferred from mutant phenotype	18056380	RGD
involved in response to ATP	IEP IEP: Inferred from expression pattern	17132626	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	23812090	RGD
involved in response to arsenic-containing substance	IEP IEP: Inferred from expression pattern	14713550	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	15482376	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	12939597	RGD
involved in response to glucose	IEP IEP: Inferred from expression pattern	16804083	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	17166883	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	18095365	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	16188065	RGD
involved in response to zinc ion	IEP IEP: Inferred from expression pattern	18054565	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendritic spine	IDA IDA: Inferred from direct assay	20628354	RGD
is active in postsynaptic cytosol	IDA IDA: Inferred from direct assay	26780512	RGD
is active in postsynaptic cytosol	IMP IMP: Inferred from mutant phenotype	26780512	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	20628354	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pten Protein Structure

PTP_PTEN

PTEN_C2

0
100
200
300
403 a.a.

Protein Preferred Names

Protein Names

phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

mutated in multiple advanced cancers 1	phosphatase and tensin homolog deleted on chromosome ten
protein tyrosine phosphatase and tensin-like protein

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-106263B	Tyroserleutide hydrochloride	Activator	99.98%	Phase 3

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13074	VO-Ohpic trihydrate	Inhibitor	≥98.0%	Unkown
HY-15842	SF1670	Inhibitor	≥98.0%	Unkown
HY-128693	BpV(HOpic)	Inhibitor	≥98.0%	Unkown
HY-N1435	Oroxin B	Activator	99.71%	Unkown
HY-N1441	Afzelin		99.62%	Unkown
HY-122818	BpV(phen) trihydrate	Inhibitor	≥98.0%	Unkown
HY-160093	SQLE-IN-1	Inducer	98.82%	Unkown
HY-N2116	Ginkgolic acid C17:1	Inhibitor	99.90%	Unkown
HY-136065	bpV(phen)	Inhibitor	≥98.0%	Unkown
HY-110067	VO-OHPic	Inhibitor	/	Unkown
HY-N8884	Coelonin	Inhibitor	/	Unkown
HY-18764	BpV(pic) potassium hydrate	Inhibitor	/	Unkown
HY-170791	CIB-L43	Activator	/	Unkown
HY-131549A	bpV(bipy) hydrate	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pten	NCBI	NCBI:5728

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