ANO7 - anoctamin 7 Gene

Homo sapiens

Also known as NGEP; DTMPP; IPCA5; D-TMPP; IPCA-5; PCANAP5; TMEM16G; PCANAP5L

Gene ID: 50636 | Gene type: protein coding

About ANO7

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:241,188,677-241,240,308 (from NCBI)

This gene has 10 transcripts (splice variants), 145 orthologues and 10 paralogues. Biased expression in prostate (RPKM 34.0), stomach (RPKM 8.3) and 3 other tissues.

Summary

This prostate-specific gene encodes a cytoplasmic protein, as well as a polytopic membrane protein which may serve as a target in prostate Cancer diagnosis and immunotherapy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2011]

ANO7 Products(2)

mRNA	Protein	Name
NM_001001666.4	NP_001001666.2	anoctamin-7 isoform 2
NM_001370694.2	NP_001357623.1	anoctamin-7 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables intracellularly calcium-gated chloride channel activity	IDA IDA: Inferred from direct assay	21984732	GOA
enables intracellularly calcium-gated chloride channel activity	IDA IDA: Inferred from direct assay	22946059	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chloride transmembrane transport	IDA IDA: Inferred from direct assay	22946059	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	22075693	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	14981236	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANO7 Protein Structure

Anoctamin

0
200
400
600
800
933 a.a.

Protein Preferred Names

Protein Names

anoctamin-7

Dresden-transmembrane protein of the prostate

Related Diseases

Diseases

Alias

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Spinocerebellar Ataxia, Autosomal Recessive 10

SCAR10	Autosomal Recessive Spinocerebellar Ataxia 10
Adult-Onset Autosomal Recessive Cerebellar Ataxia	Autosomal Recessive Spinocerebellar Ataxia Type 10
Spinocerebellar Ataxia, Autosomal Recessive, 10	Ataxia, Spinocerebellar, Autosomal Recessive, Type 10

Miyoshi Muscular Dystrophy 3

MMD3	Miyoshi Myopathy 3
Distal Anoctaminopathy	Miyoshi Muscular Dystrophy Type 3
Dystrophy, Muscular, Miyoshi, Type 3

Gnathodiaphyseal Dysplasia

GDD	Osteogenesis Imperfecta With Unusual Skeletal Lesions
Gnathodiaphyseal Sclerosis	Osteogenesis Imperfecta, Levin Type
Levin Syndrome 2	Dysplasia, Gnathodiaphyseal

Scott Syndrome

SCTS	Bdplt7
Prothrombin Consumption Deficiency	Bleeding Abnormality Due To Deficiency Of Platelet Binding Of Factor X
Bleeding Disorder, Platelet-Type, 7	Prothrombin Conversion Defect, Familial
Prothrombin Consumption Inhibitor, Familial	Bleeding Abnormality Due To Deficiency Of Platelet Biding Of Factor X
Familial Prothrombin Consumption Inhibitor	Familial Prothrombin Conversion Defect
Platelet-Type Bleeding Disorder 7	Platelet Factor X Receptor Deficiency
Bleeding Disorder Platelet-Type 7	Prothrombin Consumption Inhibitor Familial
Prothrombin Conversion Defect Familial

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00747	ANO7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ANO7	MGD	MGI:3052714
Canis familiaris	ANO7	VGNC	VGNC:59073
Felis catus	ANO7	VGNC	VGNC:59832
Rattus norvegicus	ANO7	RGD	RGD:1302987
Macaca mulatta	ANO7	VGNC	VGNC:69933

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