Mapk9 - mitogen-activated protein kinase 9 Gene

Rattus norvegicus

Also known as SAPK

Gene ID: 50658 | Gene type: protein coding

About Mapk9

Primary_assembly 10: 34,169,675-34,210,178 forward strand.mRatBN7.2:CM026983.1

This gene has 7 transcripts (splice variants), 221 orthologues, 21 paralogues and is associated with 14 phenotypes. Biased expression in Brain (RPKM 297.8), Liver (RPKM 173.) and 9 other tissues.

Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases are multifunctional proteins. They are involved in a wide variety of cellular processes such as growth, proliferation, differentiation, transcription regulation, and development. They function in stress responses, Apoptosis, inflammation and transformation. For example, this kinase plays a dominant role in mediating proliferation of lung Cancer and prostate Cancer cells, and in regulation of osmotic stress-induced tight junction disruption. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2012]

Mapk9 Products(3)

mRNA	Protein	Name
NM_001270545.1	NP_001257474.1	mitogen-activated protein kinase 9 isoform 3
NM_017322.2	NP_059018.1	mitogen-activated protein kinase 9 isoform 1
NM_001270544.1	NP_001257473.1	mitogen-activated protein kinase 9 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	10051439	RGD
enables JUN kinase activity	IDA IDA: Inferred from direct assay	10051439	RGD
enables JUN kinase activity	IMP IMP: Inferred from mutant phenotype	9786861	RGD
enables cysteine-type endopeptidase activator activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	14522843	RGD
enables mitogen-activated protein kinase kinase kinase binding	IPI IPI: Inferred from physical interaction	16006144	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10856240	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in JNK cascade	IDA IDA: Inferred from direct assay	10051439	RGD
involved in JUN phosphorylation	IMP IMP: Inferred from mutant phenotype	16942465	RGD
involved in cellular hyperosmotic response	IEP IEP: Inferred from expression pattern	10950813	RGD
involved in cellular response to UV	IMP IMP: Inferred from mutant phenotype	8875991	RGD
involved in cellular response to amyloid-beta	IEP IEP: Inferred from expression pattern	12534344	RGD
involved in cellular response to growth factor stimulus	IEP IEP: Inferred from expression pattern	17568197	RGD
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	9513050	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	9475517	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	9475517	RGD
involved in neuron development	IEP IEP: Inferred from expression pattern	17568197	RGD
involved in neuron projection development	IMP IMP: Inferred from mutant phenotype	16006144	RGD
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	15504737	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	12029621	RGD
involved in positive regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	16006144	RGD
involved in positive regulation of chemokine production	IMP IMP: Inferred from mutant phenotype	16942465	RGD
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	14522843	RGD
involved in positive regulation of nitric oxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	10593906	RGD
involved in positive regulation of nitric-oxide synthase biosynthetic process	IMP IMP: Inferred from mutant phenotype	10593906	RGD
involved in positive regulation of prostaglandin biosynthetic process	IMP IMP: Inferred from mutant phenotype	9786861	RGD
involved in positive regulation of prostaglandin secretion	IMP IMP: Inferred from mutant phenotype	9786861	RGD
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	16942465	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	10051439	RGD
involved in protein targeting to mitochondrion	IEP IEP: Inferred from expression pattern	15504737	RGD
involved in regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	17348686	RGD
involved in regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	8875991	RGD
involved in release of cytochrome c from mitochondria	IMP IMP: Inferred from mutant phenotype	15504737	RGD
involved in response to amine	IEP IEP: Inferred from expression pattern	18081878	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	16041628	RGD
involved in response to nerve growth factor	IEP IEP: Inferred from expression pattern	11356687	RGD
involved in response to tetrachloromethane	IEP IEP: Inferred from expression pattern	18081878	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	15504737	RGD
involved in response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	14522843	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	18385140	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	10950813	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mapk9 Protein Structure

STKc_JNK

0
100
200
300
400
423 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase 9

MAP kinase 9	MAPK 9
SAPK-alpha	c-Jun N-terminal kinase 2
p54-alpha	stress activated protein kinase alpha II
stress-activated protein kinase JNK2

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Purity	Rare Diseases
HY-148063	DB0614	98.80%	Unkown
HY-148061	DB1113	99.28%	Unkown
HY-RS08127	MAPK9 Human Pre-designed siRNA Set A	/	Unkown
HY-RS08128	Mapk9 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS08129	Mapk9 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mapk9	NCBI	NCBI:5601

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