TAS2R10 - taste 2 receptor member 10 Gene

Homo sapiens

Also known as TRB2; T2R10

Gene ID: 50839 | Gene type: protein coding

About TAS2R10

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:10,825,219-10,826,358 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 199 orthologues and 23 paralogues.

Summary

This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the Taste Receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the Taste Receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]

TAS2R10 Products(1)

mRNA	Protein	Name
NM_023921.2	NP_076410.1	taste receptor type 2 member 10

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables bitter taste receptor activity	IDA IDA: Inferred from direct assay	20022913	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in detection of chemical stimulus involved in sensory perception of bitter taste	IDA IDA: Inferred from direct assay	20022913	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAS2R10 Protein Structure

TAS2R

0
100
200
307 a.a.

Protein Preferred Names

Protein Names

taste receptor type 2 member 10

taste receptor, family B, member 2

TAS2R10 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TAS2R10	Q9NYW0	RTP4	Homo sapiens	Q96DX8	Y2H Prey Pooling	32296183
Intra	TAS2R10	Q9NYW0	RTP4	Homo sapiens	Q96DX8	Y2H Array	32296183
Intra	TAS2R10	Q9NYW0	PDCD1LG2	Homo sapiens	Q9BQ51	Y2H Array	32296183
Intra	TAS2R10	Q9NYW0	PDCD1LG2	Homo sapiens	Q9BQ51	Y2H Prey Pooling	32296183
Intra	TAS2R10	Q9NYW0	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	TAS2R10	Q9NYW0	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	TAS2R10	Q9NYW0	HERPUD2	Homo sapiens	Q9BSE4	Y2H Array	32296183
Intra	TAS2R10	Q9NYW0	HERPUD2	Homo sapiens	Q9BSE4	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14216	TAS2R10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TAS2R10	RGD	RGD:2314260
Canis familiaris	TAS2R10	VGNC	VGNC:47115

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