2. Gene
  3. NTM - neurotrimin Gene

NTM - neurotrimin Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HNT; NTRI; CEPU-1; IGLON2

Gene ID: 50863 | Gene type: protein coding

About NTM

Cytogenetic location: 11q25 Genomic coordinates (GRCh38): 11:131,370,615-132,336,822 (from NCBI)

This gene has 23 transcripts (splice variants), 219 orthologues and 5 paralogues. Biased expression in brain (RPKM 12.0), lung (RPKM 3.5) and 5 other tissues.

Summary

This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules. The encoded protein may promote neurite outgrowth and adhesion via a homophilic mechanism. This gene is closely linked to a related family member, opioid binding protein/cell adhesion molecule-like (OPCML), on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

NTM Products(19)

mRNA Protein Name
NM_001048209.2 NP_001041674.1 neurotrimin isoform 2 precursor
NM_001144058.2 NP_001137530.1 neurotrimin isoform 3 precursor
NM_001144059.3 NP_001137531.1 neurotrimin isoform 4 precursor
NM_001352001.2 NP_001338930.1 neurotrimin isoform 5 precursor
NM_001352002.2 NP_001338931.1 neurotrimin isoform 6 precursor
NM_001352003.2 NP_001338932.1 neurotrimin isoform 7 precursor
NM_001352004.2 NP_001338933.1 neurotrimin isoform 8 precursor
NM_001352005.2 NP_001338934.1 neurotrimin isoform 9 precursor
NM_001352006.2 NP_001338935.1 neurotrimin isoform 10
NM_001352007.2 NP_001338936.1 neurotrimin isoform 11
NM_001352008.2 NP_001338937.1 neurotrimin isoform 12
NM_001352009.2 NP_001338938.1 neurotrimin isoform 13
NM_001386964.1 NP_001373893.1 neurotrimin isoform 14
NM_001386965.1 NP_001373894.1 neurotrimin isoform 15
NM_001386966.1 NP_001373895.1 neurotrimin isoform 16
NM_001386967.1 NP_001373896.1 neurotrimin isoform 17
NM_001386968.1 NP_001373897.1 neurotrimin isoform 5
NM_001386969.1 NP_001373898.1 neurotrimin isoform 16
NM_016522.3 NP_057606.1 neurotrimin isoform 1 precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21982860 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NTM Protein Structure

I-set

I-set: Immunoglobulin I-set domain (38 - 132)

I-set

I-set: Immunoglobulin I-set domain (136 - 215)

I-set

I-set: Immunoglobulin I-set domain (230 - 310)

  • 0
  • 100
  • 200
  • 300
  • 344 a.a.
Protein Preferred Names Protein Names

neurotrimin

IgLON family member 2

NTM Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
NTM Q9P121 CCKBR Homo sapiens P32239
Y2H Prey Pooling
25416956
Intra
NTM Q9P121 CCKBR Homo sapiens P32239
Validated Y2H
25416956
Intra
NTM Q9P121 CCKBR Homo sapiens P32239
Y2H Array
25416956
Intra
NTM Q9P121 C19orf47 Homo sapiens Q8N9M1
Y2H Array
25416956
Intra
NTM Q9P121 C19orf47 Homo sapiens Q8N9M1
Validated Y2H
25416956
Intra
NTM Q9P121 KRTAP5-9 Homo sapiens P26371
Y2H Array
25416956
Intra
NTM Q9P121 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
25416956
Intra
NTM Q9P121 KRTAP5-9 Homo sapiens P26371
Validated Y2H
25416956
Intra
NTM Q9P121 LSAMP Homo sapiens Q13449
Protein Array
21982860
Intra
NTM Q9P121 NEGR1 Homo sapiens Q7Z3B1
Protein Array
21982860
Intra
NTM Q9P121 KRTAP3-2 Homo sapiens Q9BYR7
Validated Y2H
25416956
Intra
NTM Q9P121 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Prey Pooling
25416956
Intra
NTM Q9P121 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Array
31515488
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NTM Proteins

Cat. No. Product Name Accession Purity
HY-P71154 Neurotrimin Protein, Human (283a.a, HEK293, His) Q9P121-3 (G34-L316) ≥95%
HY-P74701 Neurotrimin Protein, Human (312a.a, HEK293, His) Q9P121-1 (M1-G312) ≥95%
HY-P74702 Neurotrimin Protein, Human (HEK293, Fc) Q9P121-1 (M1-G312) ≥95%

Related Diseases

Diseases Alias
Juvenile Pilocytic Astrocytoma
Jacobsen Syndrome

Chromosome 11q Deletion Syndrome

Partial 11q Monosomy Syndrome

Jacobsen Distal 11q Deletion Syndrome

JBS

11q Partial Monosomy Syndrome

Chromosome 11q Deletion

11q Deletion

11q Monosomy

Deletion 11q

Monosomy 11q

Partial Monosomy 11q

11q Deletion Disorder

11q Deletion Syndrome

11q Terminal Deletion Disorder

11q- Deletion Syndrome

11q23 Deletion Disorder

Jacobsen Thrombocytopenia

11q Terminal Deletion Syndrome

Del(11)(Q23.3)

Del(11)(Qter)

Distal Deletion 11q

Distal Monosomy 11q

Monosomy 11qter

Telomeric Deletion 11q

Paris-Trousseau Thrombocytopenia
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148478 MMV688845 Inhibitor 99.35% Unkown
HY-RS09619 NTM Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus NTM VGNC VGNC:81966
Mus musculus NTM MGD MGI:2446259
Canis familiaris NTM VGNC VGNC:44005
Bos taurus NTM VGNC VGNC:32302
Macaca mulatta NTM VGNC VGNC:75425
Rattus norvegicus NTM RGD RGD:620958
Others NTM NCBI