2. Cell Cycle/DNA Damage Anti-infection
  3. Topoisomerase Bacterial
  4. SPR719

SPR719 (VXc-486) is an orally active gyrase B inhibitor, with bactericidal activity. SPR719 potently inhibits multiple agent-sensitive isolates and drug-resistant isolates of Mycobacterium tuberculosis, with MICs of 0.03 to 0.30 μg/ml and 0.08 to 5.48 μg/ml, respectively. SPR719 is promising for research of lung disease caused by non-tuberculous mycobacteria (NTM).

For research use only. We do not sell to patients.

SPR719 Chemical Structure

SPR719 Chemical Structure

CAS No. : 1384984-18-2

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Based on 4 publication(s) in Google Scholar

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SPR719 Related Antibodies

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  • Biological Activity

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Description

SPR719 (VXc-486) is an orally active gyrase B inhibitor, with bactericidal activity. SPR719 potently inhibits multiple agent-sensitive isolates and drug-resistant isolates of Mycobacterium tuberculosis, with MICs of 0.03 to 0.30 μg/ml and 0.08 to 5.48 μg/ml, respectively. SPR719 is promising for research of lung disease caused by non-tuberculous mycobacteria (NTM)[1][2][3][4].

IC50 & Target

gyrase B[1]
In Vitro

SPR719 inhibits M. tuberculosis replication in macrophages with a MIC range of 0.125-0.25 μg/mL[1][2].

IC50 (μg/ml) of SPR719 for indicated isolate in macrophages[1]

Compound H37Ra CDC1551
SPR719 0.012 0.115

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SPR719 Related Antibodies
In Vivo

SPR719 (100 mg/kg, oral gavage, twice a day for 4 weeks) combined with pVXc-486 (30 and 100 mg/kg, oral gavage, twice a day for 4 weeks) reduces the mycobacterial burden in a model of chronic tuberculosis infection in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Chronic tuberculosis mouse model[1]
Dosage: 100 mg/kg
Administration: oral gavage, twice a day for 4 weeks
Result: Significantly reduced the median mycobacterial lung burdens in a chronic tuberculosis mouse model.
Molecular Weight

428.46

Formula

C21H25FN6O3
CAS No.
Appearance

Solid

Color

Yellow to brown

SMILES

O=C(NC1=NC2=CC(C3=CN=C(C(C)(O)C)N=C3)=C(F)C([C@@H]4OCCC4)=C2N1)NCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (46.68 mM; ultrasonic and adjust pH to 2 with HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3339 mL 11.6697 mL 23.3394 mL
5 mM 0.4668 mL 2.3339 mL 4.6679 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.50%

SDS (252 KB)

COA (249 KB) RP-HPLC (210 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3339 mL 11.6697 mL 23.3394 mL 58.3485 mL
5 mM 0.4668 mL 2.3339 mL 4.6679 mL 11.6697 mL
10 mM 0.2334 mL 1.1670 mL 2.3339 mL 5.8349 mL
15 mM 0.1556 mL 0.7780 mL 1.5560 mL 3.8899 mL
20 mM 0.1167 mL 0.5835 mL 1.1670 mL 2.9174 mL
25 mM 0.0934 mL 0.4668 mL 0.9336 mL 2.3339 mL
30 mM 0.0778 mL 0.3890 mL 0.7780 mL 1.9450 mL
40 mM 0.0583 mL 0.2917 mL 0.5835 mL 1.4587 mL
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SPR719 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SPR7191384984-18-2VXc-486SPR 719SPR-719VXc486VXc 486TopoisomeraseBacterialInhibitorinhibitorinhibit

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