BOLA1 - bolA family member 1 Gene

Homo sapiens

Also known as CGI-143

Gene ID: 51027 | Gene type: protein coding

About BOLA1

Cytogenetic location: 1q21.2 Genomic coordinates (GRCh38): 1:149,899,568-149,900,795 (from NCBI)

This gene has 4 transcripts (splice variants), 170 orthologues and 3 paralogues. Ubiquitous expression in kidney (RPKM 5.6), fat (RPKM 5.6) and 25 other tissues.

Summary

Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

BOLA1 Products(3)

mRNA	Protein	Name
NM_001321025.2	NP_001307954.1	bolA-like protein 1 precursor
NM_001321026.2	NP_001307955.1	bolA-like protein 1 precursor
NM_016074.5	NP_057158.1	bolA-like protein 1 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of iron-sulfur cluster assembly complex	IPI IPI: Inferred from physical interaction	27532772	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	22746225	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BOLA1 Protein Structure

BolA

0
100
137 a.a.

Protein Preferred Names

Protein Names

bolA-like protein 1

bolA homolog 1

BOLA1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BOLA1	Q9Y3E2	ZNF572	Homo sapiens	Q7Z3I7	Y2H Array	32296183
Intra	BOLA1	Q9Y3E2	ZNF572	Homo sapiens	Q7Z3I7	Y2H Prey Pooling	32296183
Intra	BOLA1	Q9Y3E2	HDX	Homo sapiens	Q7Z353	Y2H Array	32296183
Intra	BOLA1	Q9Y3E2	HDX	Homo sapiens	Q7Z353	Y2H Prey Pooling	32296183
Intra	BOLA1	Q9Y3E2	TXNRD3NB	Homo sapiens	Q6F5E7	Y2H Array	32296183
Intra	BOLA1	Q9Y3E2	TXNRD3NB	Homo sapiens	Q6F5E7	Y2H Prey Pooling	32296183
Intra	BOLA1	Q9Y3E2	Q86SX6-PRO_0000141650	Homo sapiens	Q86SX6-PRO_0000141650	GMS	27532772
Intra	BOLA1	Q9Y3E2	Q86SX6-PRO_0000141650	Homo sapiens	Q86SX6-PRO_0000141650	NMR	27532772
Intra	BOLA1	Q9Y3E2	Q86SX6-PRO_0000141650	Homo sapiens	Q86SX6-PRO_0000141650	CD	27532772
Intra	BOLA1	Q9Y3E2	GLRX3	Homo sapiens	O76003	Validated Y2H	25416956
Intra	BOLA1	Q9Y3E2	GLRX3	Homo sapiens	O76003	Anti Tag CoIP	33961781
Intra	BOLA1	Q9Y3E2	GLRX3	Homo sapiens	O76003	Y2H Array	32296183
Intra	BOLA1	Q9Y3E2	GLRX3	Homo sapiens	O76003	Y2H Array	25416956
Intra	BOLA1	Q9Y3E2	GLRX3	Homo sapiens	O76003	Y2H Array	29892012
Intra	BOLA1	Q9Y3E2	GLRX3	Homo sapiens	O76003	Y2H Prey Pooling	32296183
Intra	BOLA1	Q9Y3E2	BIRC2	Homo sapiens	Q13490	Y2H Array	31515488
Intra	BOLA1	Q9Y3E2	BIRC2	Homo sapiens	Q13490	Y2H Prey Pooling	32296183
Intra	BOLA1	Q9Y3E2	BIRC2	Homo sapiens	Q13490	Y2H Array	25416956
Intra	BOLA1	Q9Y3E2	BIRC2	Homo sapiens	Q13490	Y2H Array	32296183
Intra	BOLA1	Q9Y3E2	XIAP	Homo sapiens	P98170	Y2H Array	32296183
Intra	BOLA1	Q9Y3E2	XIAP	Homo sapiens	P98170	Y2H Prey Pooling	32296183
Intra	BOLA1	Q9Y3E2	BIRC7	Homo sapiens	Q96CA5	Y2H Prey Pooling	32296183
Intra	BOLA1	Q9Y3E2	BIRC7	Homo sapiens	Q96CA5	Y2H Array	32296183
Intra	BOLA1	Q9Y3E2	NFU1	Homo sapiens	Q9UMS0	MST	27532772

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BOLA1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75596	BOLA1 Protein, Human (His)	Q9Y3E2 (M1-P137)	≥95%

Related Diseases

Diseases

Alias

Multiple Mitochondrial Dysfunctions Syndrome 2 With Hyperglycinemia

Multiple Mitochondrial Dysfunctions Syndrome 2	MMDS2
Bola3 Deficiency	Multiple Mitochondrial Dysfunctions Syndrome Type 2
Mitochondrial Dysfunctions Syndrome, Multiple, Type 2

Multiple Mitochondrial Dysfunctions Syndrome

Fatal Multiple Mitochondrial Dysfunctions Syndrome	Fatal Multiple Mitochondrial Dysfunction Syndrome
Mmds	Multiple Mitochondrial Dysfunction Syndrome
Mitochondrial Dysfunctions, Multiple, Syndrome	Multiple Mitochondrial Dysfunctions Syndrome 1

Glycine Encephalopathy

Non-Ketotic Hyperglycinemia	Nonketotic Hyperglycinemia
NKH	GCE
Hyperglycinemia, Nonketotic	Hyperglycinemia Nonketotic
Infantile Glycine Encephalopathy	Encephalopathy, Glycine
Glycine Synthase Deficiency	Nka
Neonatal Glycine Encephalopathy	Classic Glycine Encephalopathy
Neonatal Nkh	Neonatal Non-Ketotic Hyperglycinemia
Infantile Nkh	Infantile Non-Ketotic Hyperglycinemia
Non-Ketotic Hyperglycinaemia	Glycine Cleavage Deficiency
Nonketotic Hyperglycinaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01571	BOLA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BOLA1	MGD	MGI:1916418
Felis catus	BOLA1	VGNC	VGNC:60147
Rattus norvegicus	BOLA1	RGD	RGD:1310586
Bos taurus	BOLA1	VGNC	VGNC:50092
Macaca mulatta	BOLA1	VGNC	VGNC:70373
Others	BOLA1	NCBI

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