2. Gene
  3. GLRX3 - glutaredoxin 3 Gene

GLRX3 - glutaredoxin 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GRX3; GRX4; GLRX4; PICOT; TXNL2; TXNL3

Gene ID: 10539 | Gene type: protein coding

About GLRX3

Cytogenetic location: 10q26.3 Genomic coordinates (GRCh38): 10:130,136,391-130,180,377 (from NCBI)

This gene has 6 transcripts (splice variants), 217 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 12.3), lymph node (RPKM 8.3) and 25 other tissues.

Summary

This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase Enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit Apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for Cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

GLRX3 Products(3)

mRNA Protein Name
NM_001199868.2 NP_001186797.1 glutaredoxin-3 isoform 1
NM_001321980.2 NP_001308909.1 glutaredoxin-3 isoform 2
NM_006541.5 NP_006532.2 glutaredoxin-3 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10636891 GOA
Biological Process GO Annotation Evidence Reference Source
involved in [2Fe-2S] cluster assembly IDA
IDA: Inferred from direct assay
27519415 GOA
involved in cell redox homeostasis IDA
IDA: Inferred from direct assay
27519415 GOA
involved in intracellular iron ion homeostasis IDA
IDA: Inferred from direct assay
27519415 GOA
involved in iron-sulfur cluster assembly IDA
IDA: Inferred from direct assay
27519415 GOA
involved in protein maturation by iron-sulfur cluster transfer IDA
IDA: Inferred from direct assay
27519415 GOA
Cellular Component GO Annotation Evidence Reference Source
part of iron-sulfur cluster assembly complex IPI
IPI: Inferred from physical interaction
22309771 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GLRX3 Protein Structure

Thioredoxin

Thioredoxin: Thioredoxin (21 - 114)

Glutaredoxin

Glutaredoxin: Glutaredoxin (147 - 210)

Glutaredoxin

Glutaredoxin: Glutaredoxin (248 - 312)

  • 0
  • 100
  • 200
  • 300
  • 335 a.a.
Protein Preferred Names Protein Names

glutaredoxin-3

PKC-interacting cousin of thioredoxin

Related Diseases

Diseases Alias
X-Linked Intellectual Disability-Short Stature-Overweight Syndrome

Mrx12

Mrx35

X-Linked Mental Retardation 12

X-Linked Mental Retardation 35
Transvestism

Dual-Role Transvestism

Fetishistic Transvestism

Cross Dresser

Transvestic Fetishism
Friedreich Ataxia

Friedreich Ataxia 1

FRDA

Friedreich Ataxia With Retained Reflexes

Frda1

Fa

Friedreich'S Ataxia

Hereditary Spinal Ataxia

Fa1

Friedreich'S Tabes

Hereditary Spinal Sclerosis

Spinocerebellar Ataxia, Friedreich

Friedreich Spinocerebellar Ataxia

Friedrich'S Ataxia
Transposition Of The Great Arteries, Dextro-Looped

Transposition Of The Great Arteries

DTGA1

Dextro-Looped Transposition Of The Great Arteries

DTGA

Congenitally Uncorrected Transposition Of The Great Arteries

Congenitally Uncorrected Transposition Of The Great Vessels

D-Tga

Isolated Ventriculoarterial Discordance

Ventriculoarterial Discordance With Atrioventricular Concordance

Dextro-Transposition Of The Great Arteries

Transposition Of The Great Vessels

Great Vessels Transposition

Transposition Of The Great Arteries, Dextro-Looped 1

Arteries, Great, Transposition, Dextro-Looped

Ventriculoarterial Discordance, Isolated

D-Transposition Of The Great Arteries

Complete Transposition

Tga

Tgv

Transposition Of Great Vessels

Transposition Of The Great Arteries Dextro-Looped 1

Dextro-Looped Transposition Of The Great Arteries 1

Discordant Ventriculoarterial Connection

Complete Transposition Of Great Vessels

Great Vessels Complete Transposition

Total Great Vessel Transposition

Transposition Of Great Arteries

Complete Tga - [Transposition Of The Great Arteries]

Tga - [Transposition Of Great Arteries]

Tgv - [Transposition Of Great Vessels]

Transposition Of Great Vessels Nos

Transposed Vessels Nos
Deficiency Anemia

Anemia

Deficiency Anemias

Anaemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05498 GLRX3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GLRX3 MGD MGI:1353653
Macaca mulatta GLRX3 VGNC VGNC:103820
Rattus norvegicus GLRX3 RGD RGD:69414
Canis familiaris GLRX3 VGNC VGNC:41275
Bos taurus GLRX3 VGNC VGNC:29417