2. Gene
  3. HDX - highly divergent homeobox Gene

HDX - highly divergent homeobox Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as CXorf43; D030011N01Rik

Gene ID: 139324 | Gene type: protein coding

About HDX

Cytogenetic location: Xq21.1 Genomic coordinates (GRCh38): X:84,317,878-84,502,453 (from NCBI)

This gene has 6 transcripts (splice variants), 200 orthologues and 17 paralogues. Low expression observed in reference dataset.

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]

HDX Products(3)

mRNA Protein Name
NM_001177478.2 NP_001170949.1 highly divergent homeobox isoform 2
NM_001177479.2 NP_001170950.1 highly divergent homeobox isoform 1
NM_144657.5 NP_653258.2 highly divergent homeobox isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
20211142 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HDX Protein Structure

Homeobox

Homeobox: Homeobox domain (438 - 495)

  • 0
  • 200
  • 400
  • 600
  • 690 a.a.
Protein Preferred Names Protein Names

highly divergent homeobox

HDX Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
HDX Q7Z353 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra
HDX Q7Z353 BOLA1 Homo sapiens Q9Y3E2
Validated Y2H
32296183
Intra
HDX Q7Z353 CTNNA3 Homo sapiens Q9UI47-2
Validated Y2H
32296183
Intra
HDX Q7Z353 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
HDX Q7Z353 SUFU Homo sapiens Q9UMX1
Validated Y2H
32296183
Intra
HDX Q7Z353 RTN4IP1 Homo sapiens Q8WWV3
Validated Y2H
32296183
Intra
HDX Q7Z353 TSGA10 Homo sapiens Q9BZW7
Validated Y2H
32296183
Intra
HDX Q7Z353 GCC1 Homo sapiens Q96CN9
Validated Y2H
32296183
Intra
HDX Q7Z353 FHL5 Homo sapiens Q5TD97
Y2H Array
32296183
Intra
HDX Q7Z353 FHL5 Homo sapiens Q5TD97
Y2H Prey Pooling
32296183
Intra
HDX Q7Z353 TTC5 Homo sapiens Q8N0Z6
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06100 HDX Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus HDX VGNC VGNC:106765
Macaca mulatta HDX VGNC VGNC:73242
Canis familiaris HDX VGNC VGNC:41632
Rattus norvegicus HDX RGD RGD:1563666
Felis catus HDX VGNC VGNC:62775
Mus musculus HDX MGD MGI:2685226