SERPINA5 - serpin family A member 5 Gene

Homo sapiens

Also known as PCI; PAI3; PAI-3; PCI-B; PROCI; PLANH3

Gene ID: 5104 | Gene type: protein coding

About SERPINA5

Cytogenetic location: 14q32.13 Genomic coordinates (GRCh38): 14:94,581,426-94,593,118 (from NCBI)

This gene has 12 transcripts (splice variants), 86 orthologues and 36 paralogues. Biased expression in testis (RPKM 322.5), adrenal (RPKM 213.7) and 6 other tissues.

Summary

The protein encoded by this gene is a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. This gene is one in a cluster of serpin genes located on the q arm of chromosome 14. This family member is a glycoprotein that can inhibit several serine proteases, including protein C and various plasminogen activators and kallikreins, and it thus plays diverse roles in hemostasis and thrombosis in multiple organs. [provided by RefSeq, Aug 2012]

SERPINA5 Products(1)

mRNA	Protein	Name
NM_000624.6	NP_000615.3	plasma serine protease inhibitor preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables acrosin binding	IPI IPI: Inferred from physical interaction	7521127	GOA
enables phosphatidylcholine binding	IDA IDA: Inferred from direct assay	9556620	GOA
enables protease binding	IPI IPI: Inferred from physical interaction	1725227	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7521127	GOA
enables retinoic acid binding	IDA IDA: Inferred from direct assay	11722589	GOA
enables serine-type endopeptidase inhibitor activity	IDA IDA: Inferred from direct assay	1725227	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of hydrolase activity	IMP IMP: Inferred from mutant phenotype	8665956	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in acrosomal membrane	IDA IDA: Inferred from direct assay	7521127	GOA
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	9556620	GOA
located in extracellular exosome	IDA IDA: Inferred from direct assay	21557262	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	1725227	GOA
located in membrane	IDA IDA: Inferred from direct assay	7521127	GOA
located in platelet alpha granule	IDA IDA: Inferred from direct assay	9556620	GOA
located in platelet dense tubular network	IDA IDA: Inferred from direct assay	9556620	GOA
part of protein C inhibitor-KLK3 complex	IDA IDA: Inferred from direct assay	1725227	GOA
part of protein C inhibitor-PLAT complex	IDA IDA: Inferred from direct assay	10340997	GOA
part of protein C inhibitor-PLAU complex	IDA IDA: Inferred from direct assay	3501295	GOA
part of protein C inhibitor-TMPRSS11E complex	IDA IDA: Inferred from direct assay	15328353	GOA
part of protein C inhibitor-TMPRSS7 complex	IDA IDA: Inferred from direct assay	15853774	GOA
part of protein C inhibitor-coagulation factor V complex	IDA IDA: Inferred from direct assay	6323392	GOA
part of protein C inhibitor-coagulation factor XI complex	IDA IDA: Inferred from direct assay	2844223	GOA
part of protein C inhibitor-coagulation factor Xa complex	IDA IDA: Inferred from direct assay	6323392	GOA
part of protein C inhibitor-plasma kallikrein complex	IDA IDA: Inferred from direct assay	2844223	GOA
part of protein C inhibitor-thrombin complex	IDA IDA: Inferred from direct assay	6323392	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	7521127	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SERPINA5 Protein Structure

Serpin

0
100
200
300
406 a.a.

Protein Preferred Names

Protein Names

plasma serine protease inhibitor

acrosomal serine protease inhibitor

Recombinant SERPINA5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70975	Serpin A5 Protein, Human (HEK293, His)	AAH08915.1 (H20-P406)	≥95%

Related Diseases

Diseases

Alias

Pontocerebellar Hypoplasia, Type 14

PCH14	Pontocerebellar Hypoplasia Type 14
Pontocerebellar Hypoplasia 14	Doid:0112325

Thrombosis

Thrombosis Of Blood Vessel

Epilepsy, Idiopathic Generalized 13

Epilepsy, Childhood Absence 4	EIG13
Epilepsy, Idiopathic Generalized, Susceptibility To, 13	Epilepsy, Childhood Absence, Susceptibility To, 4
Idiopathic Generalized Epilepsy 13	Epilepsy, Juvenile Myoclonic, Susceptibility To, 5
Epilepsy, Juvenile Myoclonic 5	ECA4
Juvenile Myoclonic Epilepsy 5	EJM5
Susceptibility To Juvenile Myoclonic Epilepsy 5	Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 13

Spherocytosis, Type 5

Hereditary Spherocytosis Type 5	SPH5
Hs5	Spherocytosis, Hereditary, 5
Hereditary Spherocytosis 5	Spherocytosis 5
Spherocytosis, Hereditary, Type 5

Varicocele

Scrotal Varices	Varicoceles
Varicocele Of Scrotum	Scrotal Varicocele

Malignant Ovarian Cyst

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12701	SERPINA5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SERPINA5	MGD	MGI:107817
Bos taurus	SERPINA5	VGNC	VGNC:53954
Macaca mulatta	SERPINA5	VGNC	VGNC:77364
Felis catus	SERPINA5	VGNC	VGNC:68725
Rattus norvegicus	SERPINA5	RGD	RGD:619817
Canis familiaris	SERPINA5	VGNC	VGNC:103705
Others	SERPINA5	NCBI

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