LACTB2 - lactamase beta 2 Gene

Homo sapiens

Also known as CGI-83

Gene ID: 51110 | Gene type: protein coding

About LACTB2

Cytogenetic location: 8q13.3 Genomic coordinates (GRCh38): 8:70,637,266-70,669,185 (from NCBI)

This gene has 4 transcripts (splice variants) and 209 orthologues. Broad expression in testis (RPKM 25.7), kidney (RPKM 23.4) and 24 other tissues.

Summary

Enables endoribonuclease activity; single-stranded RNA binding activity; and zinc ion binding activity. Involved in RNA phosphodiester bond hydrolysis, endonucleolytic. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]

LACTB2 Products(1)

mRNA	Protein	Name
NM_016027.3	NP_057111.1	endoribonuclease LACTB2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA endonuclease activity	IDA IDA: Inferred from direct assay	26826708	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables single-stranded RNA binding	IDA IDA: Inferred from direct assay	26826708	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	26826708	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	26826708	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LACTB2 Protein Structure

Lactamase_B

0
100
200
288 a.a.

Protein Preferred Names

Protein Names

endoribonuclease LACTB2

beta-lactamase-like protein 2

LACTB2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LACTB2	Q53H82	SIAH1	Homo sapiens	Q8IUQ4	Validated Y2H	25416956
Intra	LACTB2	Q53H82	SIAH1	Homo sapiens	Q8IUQ4	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LACTB2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70853	LACTB2 Protein, Human (GST)	Q53H82 (M1-L288)	≥95%

Related Diseases

Diseases

Alias

Branchiootorenal Syndrome

Branchio-Oto-Renal Syndrome	Bor Syndrome
Branchiootorenal Dysplasia	Melnick-Fraser Syndrome
Branchiootorenal Spectrum Disorders	Branchio-Otorenal Dysplasia
Branchio Oto Renal Syndrome	Branchiootorenal/Branchiootic Syndrome
Bo Syndrome	Bor
Bos	Branchio-Otorenal Syndrome
Branchiootic Syndrome	Branchiootorenal Syndrome
Branchiootic Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07490	LACTB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	LACTB2	VGNC	VGNC:30765
Macaca mulatta	LACTB2	VGNC	VGNC:74072
Mus musculus	LACTB2	MGD	MGI:2442551
Felis catus	LACTB2	VGNC	VGNC:63186
Rattus norvegicus	LACTB2	RGD	RGD:1307876
Canis familiaris	LACTB2	VGNC	VGNC:42560
Others	LACTB2	NCBI

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