SERPINA10 - serpin family A member 10 Gene

Homo sapiens

Also known as PZI; ZPI

Gene ID: 51156 | Gene type: protein coding

About SERPINA10

Cytogenetic location: 14q32.13 Genomic coordinates (GRCh38): 14:94,280,460-94,293,268 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 256 orthologues, 36 paralogues and is associated with 1 phenotype. Restricted expression toward liver (RPKM 44.6).

Summary

The protein encoded by this gene belongs to the serpin family. It is predominantly expressed in the liver and secreted in plasma. It inhibits the activity of coagulation factors Xa and XIa in the presence of protein Z, calcium and phospholipid. Mutations in this gene are associated with venous thrombosis. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, May 2010]

SERPINA10 Products(2)

mRNA	Protein	Name
NM_001100607.3	NP_001094077.1	protein Z-dependent protease inhibitor precursor
NM_016186.3	NP_057270.1	protein Z-dependent protease inhibitor precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20427285	GOA

Biological Process GO Annotation	Evidence	Reference	Source
NOT involved in regulation of acrosome reaction	IDA IDA: Inferred from direct assay	11751269	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SERPINA10 Protein Structure

Serpin

0
100
200
300
400
444 a.a.

Protein Preferred Names

Protein Names

protein Z-dependent protease inhibitor

PZ-dependent protease inhibitor

Recombinant SERPINA10 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71292	Serpin A10 Protein, Human (HEK293, His)	Q9UK55 (L22-L444)	≥95%

Related Diseases

Diseases

Alias

Thrombosis

Thrombosis Of Blood Vessel

Protein Z Deficiency

Thrombophilia

Hypercoagulability State

Shwartzman Phenomenon

Shwartzman Reaction

Amelogenesis Imperfecta

Ai	Congenital Enamel Hypoplasia
Al - [Amelogenesis Imperfecta]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12697	SERPINA10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SERPINA10	RGD	RGD:621220
Mus musculus	SERPINA10	MGD	MGI:2667725
Macaca mulatta	SERPINA10	VGNC	VGNC:77242
Bos taurus	SERPINA10	VGNC	VGNC:34465
Others	SERPINA10	NCBI

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