AADAT - aminoadipate aminotransferase Gene

Homo sapiens

Also known as KAT2; KATII; KYAT2

Gene ID: 51166 | Gene type: protein coding

About AADAT

Cytogenetic location: 4q33 Genomic coordinates (GRCh38): 4:170,060,222-170,094,292 (from NCBI)

This gene has 8 transcripts (splice variants), 230 orthologues and 7 paralogues. Broad expression in liver (RPKM 11.4), prostate (RPKM 6.3) and 19 other tissues.

Summary

This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The Other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

AADAT Products(4)

mRNA	Protein	Name
NM_001286682.2	NP_001273611.1	kynurenine/alpha-aminoadipate aminotransferase, mitochondrial isoform a
NM_001286683.1	NP_001273612.1	kynurenine/alpha-aminoadipate aminotransferase, mitochondrial isoform b
NM_016228.4	NP_057312.1	kynurenine/alpha-aminoadipate aminotransferase, mitochondrial isoform b
NM_182662.2	NP_872603.1	kynurenine/alpha-aminoadipate aminotransferase, mitochondrial isoform b

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables 2-aminoadipate transaminase activity	IDA IDA: Inferred from direct assay	18620547	GOA
enables glycine:2-oxoglutarate aminotransferase activity	IDA IDA: Inferred from direct assay	18620547	GOA
enables kynurenine-glyoxylate transaminase activity	IDA IDA: Inferred from direct assay	18620547	GOA
enables kynurenine-oxoglutarate transaminase activity	IDA IDA: Inferred from direct assay	18620547	GOA
enables methionine-glyoxylate transaminase activity	IDA IDA: Inferred from direct assay	18620547	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	18620547	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in 2-oxoglutarate metabolic process	IDA IDA: Inferred from direct assay	18620547	GOA
involved in glutamate metabolic process	IDA IDA: Inferred from direct assay	18620547	GOA
involved in kynurenine metabolic process	IDA IDA: Inferred from direct assay	18620547	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AADAT Protein Structure

Aminotran_1_2

0
100
200
300
400
425 a.a.

Protein Preferred Names

Protein Names

kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

2-aminoadipate aminotransferase

Related Diseases

Diseases

Alias

Hydroxykynureninuria

Xanthurenic Aciduria	Kynureninase Deficiency
Kynureninase Deficiency, Partial	HYXKY
Partial Kynureninase Deficiency

Detrusor Sphincter Dyssynergia

Detrusor And Sphincter Dyssynergia

Huntington Disease

Huntington'S Disease	Huntington Chorea
Huntington'S Chorea	HD
Huntington Chronic Progressive Hereditary Chorea	Juvenile Huntington Disease
Chronic Progressive Chorea	Chronic Progressive Hereditary Chorea
Hc - [Huntington Chorea]	Hereditary Chorea
Progressive Hereditary Chorea

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00018	AADAT Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AADAT	RGD	RGD:2948
Mus musculus	AADAT	MGD	MGI:1345167
Canis familiaris	AADAT	VGNC	VGNC:37407
Bos taurus	AADAT	VGNC	VGNC:25440
Felis catus	AADAT	VGNC	VGNC:59449
Macaca mulatta	AADAT	VGNC	VGNC:69454

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