NUSAP1 - nucleolar and spindle associated protein 1 Gene

Homo sapiens

Also known as LNP; ANKT; SAPL; BM037; NUSAP; Q0310; PRO0310p1

Gene ID: 51203 | Gene type: protein coding

About NUSAP1

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:41,332,881-41,381,046 (from NCBI)

This gene has 14 transcripts (splice variants) and 205 orthologues. Broad expression in bone marrow (RPKM 30.9), lymph node (RPKM 16.8) and 15 other tissues.

Summary

NUSAP1 is a nucleolar-spindle-associated protein that plays a role in spindle microtubule organization (Raemaekers et al., 2003 [PubMed 12963707]).[supplied by OMIM, Jun 2009]

NUSAP1 Products(6)

mRNA	Protein	Name
NM_001243142.2	NP_001230071.1	nucleolar and spindle-associated protein 1 isoform 4
NM_001243143.2	NP_001230072.1	nucleolar and spindle-associated protein 1 isoform 5
NM_001243144.2	NP_001230073.1	nucleolar and spindle-associated protein 1 isoform 6
NM_001301136.2	NP_001288065.1	nucleolar and spindle-associated protein 1 isoform 7
NM_016359.5	NP_057443.2	nucleolar and spindle-associated protein 1 isoform 1
NM_018454.8	NP_060924.4	nucleolar and spindle-associated protein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within establishment of mitotic spindle localization	IDA IDA: Inferred from direct assay	12963707	GOA
acts upstream of or within mitotic chromosome condensation	IDA IDA: Inferred from direct assay	12963707	GOA
acts upstream of or within mitotic cytokinesis	IDA IDA: Inferred from direct assay	12963707	GOA
acts upstream of or within mitotic sister chromatid segregation	IDA IDA: Inferred from direct assay	12963707	GOA
acts upstream of or within positive regulation of mitotic nuclear division	IDA IDA: Inferred from direct assay	12963707	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nucleolar and spindle-associated protein 1

nucleolar protein ANKT

Related Diseases

Diseases

Alias

Microcephaly, Seizures, And Developmental Delay

MCSZ	Developmental And Epileptic Encephalopathy 10
Epileptic Encephalopathy, Early Infantile, 10	Eiee10
Dee10	Early Infantile Epileptic Encephalopathy 10

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09704	NUSAP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NUSAP1	VGNC	VGNC:32370
Canis familiaris	NUSAP1	VGNC	VGNC:44067
Rattus norvegicus	NUSAP1	RGD	RGD:1305764
Felis catus	NUSAP1	VGNC	VGNC:63932
Macaca mulatta	NUSAP1	VGNC	VGNC:75431
Mus musculus	NUSAP1	MGD	MGI:2675669

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