ZDHHC3 - zinc finger DHHC-type palmitoyltransferase 3 Gene

Homo sapiens

Also known as GODZ; DHHC3; DHHC-3; ZNF373

Gene ID: 51304 | Gene type: protein coding

About ZDHHC3

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:44,915,261-44,976,174 (from NCBI)

This gene has 12 transcripts (splice variants), 292 orthologues and 17 paralogues. Ubiquitous expression in testis (RPKM 9.5), skin (RPKM 8.8) and 25 other tissues.

Summary

Enables palmitoyltransferase activity. Involved in several processes, including TRAIL-activated apoptotic signaling pathway; protein localization to membrane; and protein localization to photoreceptor outer segment. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]

ZDHHC3 Products(9)

mRNA	Protein	Name
NM_001135179.2	NP_001128651.1	palmitoyltransferase ZDHHC3 isoform 1
NM_001330761.2	NP_001317690.1	palmitoyltransferase ZDHHC3 isoform 4
NM_001349376.2	NP_001336305.1	palmitoyltransferase ZDHHC3 isoform 5
NM_001349377.2	NP_001336306.1	palmitoyltransferase ZDHHC3 isoform 6
NM_001349378.2	NP_001336307.1	palmitoyltransferase ZDHHC3 isoform 7
NM_001349379.2	NP_001336308.1	palmitoyltransferase ZDHHC3 isoform 8
NM_001349380.2	NP_001336309.1	palmitoyltransferase ZDHHC3 isoform 1
NM_001349381.2	NP_001336310.1	palmitoyltransferase ZDHHC3 isoform 1
NM_016598.3	NP_057682.1	palmitoyltransferase ZDHHC3 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables palmitoyltransferase activity	IDA IDA: Inferred from direct assay	21926431	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in TRAIL-activated apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	22240897	GOA
involved in lipoprotein localization to membrane	IMP IMP: Inferred from mutant phenotype	22240897	GOA
involved in positive regulation of toll-like receptor 9 signaling pathway	IDA IDA: Inferred from direct assay	38169466	GOA
involved in protein localization to photoreceptor outer segment	IDA IDA: Inferred from direct assay	27613864	GOA
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	22240897	GOA
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	19001095	GOA
involved in protein palmitoylation	IDA IDA: Inferred from direct assay	21926431	GOA
involved in protein palmitoylation	IMP IMP: Inferred from mutant phenotype	19001095	GOA
involved in regulation of G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19001095	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Golgi apparatus	IDA IDA: Inferred from direct assay	27613864	GOA
located in Golgi apparatus	IDA IDA: Inferred from direct assay	16647879	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZDHHC3 Protein Structure

DHHC

0
100
200
299 a.a.

Protein Preferred Names

Protein Names

palmitoyltransferase ZDHHC3

DHHC1 protein

Related Diseases

Diseases

Alias

Neuronal Ceroid Lipofuscinosis

Hereditary Ceroid Lipofuscinosis	Batten Disease
Ncl	Neuronal Ceroid-Lipofuscinoses
Lipofuscinosis, Ceroid, Neuronal	Juvenile Neuronal Ceroid Lipofuscinosis
Cerebromacular Dystrophy	Cerebromacular Degeneration
Ceroid-Lipofuscinosis	Ncl - [Neuronal Ceroid Lipofuscinosis]
Amaurotic Familial Idiocy	Amaurotic Idiocy
Amaurotic Idiot	Neuronal Lipofuscinosis
Pigmentary Retinal Lipoid Neuronal Heredodegeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16021	ZDHHC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ZDHHC3	RGD	RGD:1309041
Bos taurus	ZDHHC3	VGNC	VGNC:37141
Macaca mulatta	ZDHHC3	VGNC	VGNC:79143
Mus musculus	ZDHHC3	MGD	MGI:1926134
Canis familiaris	ZDHHC3	VGNC	VGNC:48591
Felis catus	ZDHHC3	VGNC	VGNC:67214

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