PDC - phosducin Gene

Homo sapiens

Also known as PHD; MEKA; PhLP; PhLOP

Gene ID: 5132 | Gene type: protein coding

About PDC

Cytogenetic location: 1q31.1 Genomic coordinates (GRCh38): 1:186,443,566-186,461,114 (from NCBI)

This gene has 2 transcripts (splice variants), 269 orthologues and 4 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a phosphoprotein, which is located in the outer and inner segments of the rod cells in the retina. This protein may participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. It modulates the phototransduction cascade by interacting with the beta and gamma subunits of the retinal G-protein transducin. This gene is a potential candidate gene for retinitis pigmentosa and Usher syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

PDC Products(2)

mRNA	Protein	Name
NM_002597.5	NP_002588.3	phosducin isoform a
NM_022576.4	NP_072098.1	phosducin isoform b

PDC Protein Structure

Phosducin

0
100
200
246 a.a.

Protein Preferred Names

Protein Names

phosducin

33 kDa phototransducing protein

Related Diseases

Diseases

Alias

Pollen Allergy

Hay Fever

Tomato Allergy

Solanum Lycopersicum Fruit Allergy

Timothy Grass Allergy

Melon Allergy

Cucumis Melo Fruit Allergy

Orange Allergy

Citrus Sinensis Fruit Allergy

Apple Allergy

Malus Domestica Fruit Allergy

Thunderstorm Triggered Asthma

Thunderstorm Asthma

Thunderstorm Related Asthma

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Peach Allergy

Prunus Persica Fruit Allergy

Fish Allergy

Allergy To Fish

Splenic Flexure Cancer

Ca Splenic Flexure - Colon	Malignant Neoplasm Of Splenic Flexure
Malignant Tumor Of Splenic Flexure	Malignant Neoplasm Of Splenic Flexure Of Colon

Usher Syndrome

Deafness-Retinitis Pigmentosa Syndrome	Dystrophia Retinae Pigmentosa-Dysostosis Syndrome
Graefe-Usher Syndrome	Hallgren Syndrome
Usher'S Syndrome	Retinitis Pigmentosa-Deafness Syndrome
Retinitis Pigmentosa-Hearing Loss Syndrome	Ush
Usher Syndromes

Fruit Allergy

Allergy To Fruit

Legume Allergy

Fabaceae Allergy

Respiratory Allergy

Airway Allergy

Nasal Cavity Disease

Disorder Of Nasal Cavity

Nose Disease

Nose Diseases	Disorder Of The Nose
Nasal Disorder	Abnormality Of The Nose

Leber Plus Disease

Leber Congenital Amaurosis	Lca
Leber'S Amaurosis	Leber'S Disease
Amaurosis Congenita Of Leber	Amaurosis Congenita Of Leber, Type 1
Lhon Plus Disease	Congenital Absence Of The Rods And Cones
Congenital Retinal Blindness	Crb
Congenital Amaurosis Of Retinal Origin	Leber'S Congenital Amaurosis
Leber Congenital Amaurosis 1	Leber'S Congenital Tapetoretinal Degeneration
Leber'S Congenital Tapetoretinal Dysplasia	Lca1
Leber Congenital Amaurosis Type 1	Retinal Blindness, Congenital
Amaurosis, Leber Congenital	Dysgenesis Neuroepithelialis Retinae
Hereditary Epithelial Dysplasia Of Retina	Hereditary Retinal Aplasia
Heredoretinopathia Congenitalis	Leber Abiotrophy
Leber Congenital Tapetoretinal Degeneration	Lebers Congenital Amaurosis
Optic Atrophy, Hereditary, Leber

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99536	Tagraxofusp	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-148511	Vidutolimod	Agonist	/	Phase 3
HY-139567	Afimetoran		98.76%	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99226	Daxdilimab		≥95.0%	Phase 2

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12836A	IFN alpha-IFNAR-IN-1 hydrochloride	Inhibitor	99.87%	Unkown
HY-150741	ODN 2216		/	Unkown
HY-132296	GSK215	Inhibitor	99.85%	Unkown
HY-150741C	ODN 2216 sodium	Activator	97.88%	Unkown
HY-148511A	Vidutolimod sodium	Inhibitor	90.20%	Unkown
HY-P4160	PDC31	Inhibitor	99.76%	Unkown
HY-12836	IFN alpha-IFNAR-IN-1	Inhibitor	/	Unkown
HY-155393	PROTAC BRD4 Degrader-22		/	Unkown
HY-160231	ssRNA42 sodium	Activator	/	Unkown
HY-P1094	AZ-10417808	Inhibitor	/	Unkown
HY-RS10184	PDC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PDC	VGNC	VGNC:106467
Canis familiaris	PDC	VGNC	VGNC:44333
Mus musculus	PDC	MGD	MGI:98090
Bos taurus	PDC	VGNC	VGNC:32656
Rattus norvegicus	PDC	RGD	RGD:3277
Macaca fascicularis	PDC	NCBI	NCBI:102141993
Others	PDC	NCBI

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