2. Immunology/Inflammation
  3. Interleukin Related
  4. Tagraxofusp

Tagraxofusp  (Synonyms: SL-401)

Cat. No.: HY-P99536

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Tagraxofusp (SL-401) is a potent IL-3 receptor inhibitor to inhibits plasmacytoid dendritic cells (pDCs) growth in multiple myeloma (MM) bone marrow (BM) microenvironment. Tagraxofusp has synergistic effect with Bortezomib (HY-10227) and Pomalidomide (HY-10984) to suppress multiple myeloma (MM).

For research use only. We do not sell to patients.

CAS No. : 2055491-00-2

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Tagraxofusp Related Antibodies

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Description

Tagraxofusp (SL-401) is a potent IL-3 receptor inhibitor to inhibits plasmacytoid dendritic cells (pDCs) growth in multiple myeloma (MM) bone marrow (BM) microenvironment. Tagraxofusp has synergistic effect with Bortezomib (HY-10227) and Pomalidomide (HY-10984) to suppress multiple myeloma (MM)[1].

Species

Human
IC50 & Target[1]

IL-3

 

In Vitro

Tagraxofusp (0-1367 pM; 72 h) inhibits pDCs viability, as well as pDC-induced proliferation of MM cells. Tagraxofusp (0-136.7 pM; 2-3 weeks) inhibits osteoclast formation and bone resorption, as well as stabilizes osteoblast formation[1].
Tagraxofusp (0-13.67 nM; 48 h) targets tumor-initiating stem-like cells in MM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tagraxofusp Related Antibodies

Cell Viability Assay[1]

Cell Line: Cancer stem-like cells in MM
Concentration: 0 nM, 0.013 nM, 0.13 nM, 1.3 nM, 13.67 nM
Incubation Time: 48 hours
Result: Inhibits cancer stem-like cells with s of 30 pM (pDCs), 50 nM (MM-SP-Oct4 cells), 75 pM (RPMI-8226-Oct4 cells), 350 pM (MM-SP cells), and 1367 pM (RPMI-8226 cells), respectively.
In Vivo

Tagraxofusp (12-50 μg/kg; i.v.; 5 times per week for 3 weeks) blocks pDC-induced tumor growth and prolongs SCID-hu mice survival in subcutaneous INA-6 MM xenograft model[1].
Tagraxofusp (16 μg/kg; i.v.; 5 times per week for 1 weeks) enhances the anti-MM activity of 2.5 mg/kg Pomalidomide in CB-17 mice of subcutaneous MM xenograft model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID-hu mice with INA-6 MM cells[1]
Dosage: 12 μg/kg, 16 μg/kg, 25 μg/kg and 50 μg/kg
Administration: Intravenous injection; for 5 consecutive days each week for 3 weeks
Result: Blocked pDC-induced tumor growth and prolonged mice survival at 12 μg/kg.
Showed well tolerance at 16 μg/kg, while higher doses resulted in body weight decrease and toxicity.
Animal Model: CB-17 mice with subcutaneous MM xenograft model[1]
Dosage: 16 μg/kg; with or without 2.5 mg/kg Pomalidomide (p.o.; 4 consecutive days weekly for 2 weeks)
Administration: Intravenous injection; dose at 5 consecutive days for first week
Result: Enhanced the anti-MM activity of proteasome inhibitor and immunomodulatory drug pomalidomide.
Clinical Trial
CAS No.
SMILES

[Tagraxofusp]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Corynebacterium diphtheriae toxin (Pr1,26-411)-IL3 (interleukin 3, interleukin 3 (colony-stimulating factor, multiple))
Purity & Documentation
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Tagraxofusp Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tagraxofusp2055491-00-2SL-401SL401SL 401Interleukin RelatedILInhibitorinhibitorinhibit

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