TRPV2 - transient receptor potential cation channel subfamily V member 2 Gene

Homo sapiens

Also known as VRL; VRL1; VRL-1

Gene ID: 51393 | Gene type: protein coding

About TRPV2

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:16,415,571-16,437,003 (from NCBI)

This gene has 9 transcripts (splice variants), 263 orthologues and 5 paralogues. Broad expression in lung (RPKM 13.6), spleen (RPKM 9.9) and 23 other tissues.

Summary

This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in Other tissues the channel may be activated by stimuli Other than heat. [provided by RefSeq, Jul 2008]

TRPV2 Products(1)

mRNA	Protein	Name
NM_016113.5	NP_057197.2	transient receptor potential cation channel subfamily V member 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables monoatomic cation channel activity	IDA IDA: Inferred from direct assay	10201375	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	34158856	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within response to temperature stimulus	IDA IDA: Inferred from direct assay	10201375	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	10201375	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRPV2 Protein Structure

Ank_2

Ion_trans

0
200
400
600
764 a.a.

Protein Preferred Names

Protein Names

transient receptor potential cation channel subfamily V member 2

OTRPC2

Related Diseases

Diseases

Alias

Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques

Olmsted Syndrome	Mutilating Palmoplantar Hyperkeratosis With Periorificial Keratotic Plaques
Palmoplantar And Periorificial Keratoderma	Olms

Scapuloperoneal Spinal Muscular Atrophy

SPSMA	Amyotrophy, Neurogenic Scapuloperoneal, New England Type
Neurogenic Scapuloperoneal Amyotrophy, New England Type	Scapuloperoneal Neuronopathy
Spinal Muscular Atrophy, Scapuloperoneal	Amyotrophy Neurogenic Scapuloperoneal New England Type
Muscular Atrophy, Spinal	Scapuloperoneal Form Of Spinal Muscular Atrophy

Brachyolmia

Brachyrachia

Dentin Sensitivity

Sensitive Dentin

Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema

Dehydrated Hereditary Stomatocytosis	Hereditary Xerocytosis
Xerocytosis, Hereditary	Pshk1
Pseudohyperkalemia Edinburgh	Dehydrated Hereditary Stomatocytosis With Or Without Pseudohyperkalemia And/Or Perinatal Edema
DHS1	Dhs
Hereditary Desiccytosis	Dehydrated Hereditary Stomatocytosis 1
Desiccytosis, Hereditary	Pseudohyperkalemia, Familial, 1, Due To Red Cell Leak
Pseudohyperkalemia Familial 1, Due To Red Cell Leak	Desiccytosis Hereditary
Xerocytosis Hereditary	Familial Pseudohyperkalemia 1 Due To Red Cell Leak
Stomatocytosis, Dehydrated, Hereditary, With/Without Pseudohyperkalemia And/Or Perinatal Edema	Xerocytosis

Lennox-Gastaut Syndrome

Lennox Syndrome	Encephalopathy Of Childhood
Epileptic Encephalopathy Lennox-Gastaut Type	Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves
Lgs

Dravet Syndrome

Severe Myoclonic Epilepsy Of Infancy	Severe Myoclonic Epilepsy In Infancy
Smei	Epileptic Encephalopathy, Early Infantile, 6
DRVT	Developmental And Epileptic Encephalopathy 6a
Dee6a	Eiee6
Developmental And Epileptic Encephalopathy, 6	Dee6
Developmental And Epileptic Encephalopathy 6	Early Infantile Epileptic Encephalopathy 6
Myoclonic Epilepsy, Severe, Of Infancy	Sme
Severe Myoclonus Epilepsy Of Infancy	Borderline Smei
Smeb	Smeb-M
Smeb-O	Smeb-Sw
Smei-Borderland	Smei-Borderland More Than One Feature
Smei-Borderland-Myoclonic Seizures	Smei-Borderland-Spike Wave
Intractable Childhood Epilepsy With Generalized Tonic-Clonic Seizures	ICEGTC
Infantile Severe Myoclonic Epilepsy	Epilepsy, Intractable Childhood, With Generalized Tonic-Clonic Seizures

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0545	Probenecid		99.95%	Yes

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-132222	SET2	Antagonist	99.72%	Unkown
HY-N8264	Moringin	Agonist	99.95%	Unkown
HY-157131	TRPV2-selective blocker 1	Inhibitor	99.84%	Unkown
HY-B0545R	Probenecid (Standard)		99.00%	Unkown
HY-RS15122	TRPV2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-N3230	Murpanicin	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TRPV2	MGD	MGI:1341836
Rattus norvegicus	TRPV2	RGD	RGD:3965
Canis familiaris	TRPV2	VGNC	VGNC:47883
Macaca mulatta	TRPV2	VGNC	VGNC:79111
Felis catus	TRPV2	VGNC	VGNC:66596
Bos taurus	TRPV2	VGNC	VGNC:36398

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