PPME1 - protein phosphatase methylesterase 1 Gene

Homo sapiens

Also known as PME-1; ABDH19

Gene ID: 51400 | Gene type: protein coding

About PPME1

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:74,171,289-74,254,703 (from NCBI)

This gene has 9 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in testis (RPKM 18.8), brain (RPKM 17.5) and 25 other tissues.

Summary

This gene encodes a protein Phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

PPME1 Products(2)

mRNA	Protein	Name
NM_001271593.2	NP_001258522.1	protein phosphatase methylesterase 1 isoform b
NM_016147.3	NP_057231.1	protein phosphatase methylesterase 1 isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein C-terminal methylesterase activity	IDA IDA: Inferred from direct assay	10318862	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22167190	GOA
enables protein phosphatase 2A binding	IDA IDA: Inferred from direct assay	10318862	GOA
enables protein phosphatase binding	IDA IDA: Inferred from direct assay	10318862	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein demethylation	IDA IDA: Inferred from direct assay	10318862	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPME1 Protein Structure

Abhydrolase_6

0
100
200
300
386 a.a.

Protein Preferred Names

Protein Names

protein phosphatase methylesterase 1

testicular secretory protein Li 39

Related Diseases

Diseases

Alias

Alzheimer Disease 15

AD15	Alzheimer'S Disease 15
Alzheimer Disease Without Neurofibrillary Tangles	Alzheimer'S Disease 15, Late Onset
Alzheimer'S Disease Without Neurofibrillary Tangles

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect Pre-designed Sets	Purity	Rare Diseases Unkown
HY-RS10971	PPME1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PPME1	RGD	RGD:1309683
Macaca mulatta	PPME1	VGNC	VGNC:76345
Mus musculus	PPME1	MGD	MGI:1919840
Felis catus	PPME1	VGNC	VGNC:64316
Canis familiaris	PPME1	VGNC	VGNC:44873
Bos taurus	PPME1	VGNC	VGNC:33218

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