NOL7 - nucleolar protein 7 Gene

Homo sapiens

Also known as PQBP3; RARG-1; C6orf90; dJ223E5.2

Gene ID: 51406 | Gene type: protein coding

About NOL7

Cytogenetic location: 6p23 Genomic coordinates (GRCh38): 6:13,615,335-13,632,470 (from NCBI)

This gene has 3 transcripts (splice variants) and 183 orthologues. Ubiquitous expression in testis (RPKM 25.5), thyroid (RPKM 22.2) and 25 other tissues.

Summary

The protein encoded by this gene localizes to the nucleolus, where it maintains nucleolar structure and cell growth rates. The encoded protein also functions as a tumor suppressor and regulator of angiogenesis. The RB tumor suppressor gene recruits transcription factors to this gene and positively regulates its expression. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]

NOL7 Products(2)

mRNA	Protein	Name
NM_001317724.2	NP_001304653.1	nucleolar protein 7
NM_016167.5	NP_057251.2	nucleolar protein 7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in maturation of SSU-rRNA	IMP IMP: Inferred from mutant phenotype	37246770	GOA
involved in ribosomal small subunit biogenesis	IDA IDA: Inferred from direct assay	34516797	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of small-subunit processome	IDA IDA: Inferred from direct assay	34516797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOL7 Protein Structure

NUC129

0
100
200
257 a.a.

Protein Preferred Names

Protein Names

nucleolar protein 7

nucleolar protein 7, 27kDa

Related Diseases

Diseases

Alias

Renpenning Syndrome 1

Renpenning Syndrome	Golabi-Ito-Hall Syndrome
Mrxs3	Mrxs8
X-Linked Intellectual Disability Due To Pqbp1 Mutations	RENS1
Sutherland-Haan X-Linked Mental Retardation Syndrome	Shs
Mrx55	X-Linked Intellectual Disability, Renpenning Type
Sutherland-Haan Syndrome	Mental Retardation, X-Linked, Renpenning Type
Mental Retardation, X-Linked, With Spastic Diplegia	Mental Retardation, X-Linked, Syndromic 3
Mental Retardation, X-Linked, Syndromic 8	Mental Retardation, X-Linked 55
Syndromic X-Linked Mental Retardation 8	X-Linked Mental Retardation Renpenning Type
X-Linked Mental Retardation With Spastic Diplegia	Sutherland-Haan X-Linked Intellectual Disability Syndrome
X-Linked Intellectual Disability With Spastic Diplegia	Hamel Cerebropalatocardiac Syndrome
Porteous Syndrome	X-Linked Intellectual Deficit Due To Pqbp1 Mutations
X-Linked Intellectual Deficit, Renpenning Type	X-Linked Intellectual Disability, Sutherland-Haan Type
Hamel Cerebro-Palato-Cardiac Syndrome	Renpenning Syndrome, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09417	NOL7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NOL7	VGNC	VGNC:32159
Macaca mulatta	NOL7	VGNC	VGNC:75226
Mus musculus	NOL7	MGD	MGI:1917328
Rattus norvegicus	NOL7	RGD	RGD:1565934
Canis familiaris	NOL7	VGNC	VGNC:43884
Felis catus	NOL7	VGNC	VGNC:102476

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