ANAPC5 - anaphase promoting complex subunit 5 Gene

Homo sapiens

Also known as APC5

Gene ID: 51433 | Gene type: protein coding

About ANAPC5

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:121,308,245-121,354,209 (from NCBI)

This gene has 22 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in lymph node (RPKM 32.0), bone marrow (RPKM 28.9) and 25 other tissues.

Summary

This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin Ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008]

ANAPC5 Products(3)

mRNA	Protein	Name
NM_001137559.1	NP_001131031.1	anaphase-promoting complex subunit 5 isoform b
NM_001330489.2	NP_001317418.1	anaphase-promoting complex subunit 5 isoform c
NM_016237.5	NP_057321.2	anaphase-promoting complex subunit 5 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	21241890	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in anaphase-promoting complex-dependent catabolic process	IDA IDA: Inferred from direct assay	29033132	GOA
involved in protein K11-linked ubiquitination	IDA IDA: Inferred from direct assay	18485873	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	29033132	GOA
involved in protein branched polyubiquitination	IDA IDA: Inferred from direct assay	29033132	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of anaphase-promoting complex	IDA IDA: Inferred from direct assay	16364912	GOA
part of anaphase-promoting complex	IPI IPI: Inferred from physical interaction	27120157	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18445686	GOA
located in spindle	IDA IDA: Inferred from direct assay	18445686	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANAPC5 Protein Structure

ANAPC5

0
200
400
600
755 a.a.

Protein Preferred Names

Protein Names

anaphase-promoting complex subunit 5

cyclosome subunit 5

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00682	ANAPC5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ANAPC5	MGD	MGI:1929722
Macaca mulatta	ANAPC5	VGNC	VGNC:99883
Bos taurus	ANAPC5	VGNC	VGNC:25885
Canis familiaris	ANAPC5	VGNC	VGNC:37851
Felis catus	ANAPC5	VGNC	VGNC:59776
Rattus norvegicus	ANAPC5	RGD	RGD:1306125

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